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Protein Page:
HuR (human)

Overview
HuR Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with ANP32A, EIF2C1 and EIF2C2. Ubiquitous. Belongs to the RRM elav family. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus
Molecular Function: AU-rich element binding; double-stranded RNA binding; mRNA 3'-UTR binding; mRNA binding; protein binding; protein homodimerization activity; protein kinase binding; RNA binding
Biological Process: mRNA stabilization; multicellular organismal development; nuclear mRNA splicing, via spliceosome; positive regulation of translation; regulation of mRNA stability
Reference #:  Q15717 (UniProtKB)
Alt. Names/Synonyms: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV-like protein 1; ELAV1; ELAVL1; embryonic lethal, abnormal vision, drosophila, homolog-like 1; Hu antigen R; Hu-antigen R; Hua; HUR; MelG
Gene Symbols: ELAVL1
Molecular weight: 36,092 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HuR

Protein Structure Not Found.
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