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Protein Page:
ABCC1 (mouse)

Overview
ABCC1 a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Cellular Component: basolateral plasma membrane; cytoplasm; integral to plasma membrane; membrane; plasma membrane
Molecular Function: ATPase activity; drug transporter activity; efflux transmembrane transporter activity; glutathione S-conjugate-exporting ATPase activity; lipid-transporting ATPase activity; long-chain fatty acid transporter activity; sphingolipid transporter activity; xenobiotic-transporting ATPase activity
Biological Process: daunorubicin transport; drug export; multidrug transport; phospholipid efflux; plasma membrane long-chain fatty acid transport; positive regulation of cell migration; response to drug; response to oxidative stress; transmembrane transport; xenobiotic transport
Reference #:  O35379 (UniProtKB)
Alt. Names/Synonyms: Abcc1; Abcc1a; Abcc1b; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; Leukotriene C(4) transporter; LTC4 transporter; Mdrap; Mrp; Mrp1; Multidrug resistance-associated protein 1; multiple drug resistance-associated protein
Gene Symbols: Abcc1
Molecular weight: 171,185 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
Select Structure to View Below

ABCC1

Protein Structure Not Found.
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