a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transporter; Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: basolateral plasma membrane; cytoplasm; integral to membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; drug transporter activity; efflux transmembrane transporter activity; glutathione S-conjugate-exporting ATPase activity; hydrolase activity; lipid-transporting ATPase activity; long-chain fatty acid transporter activity; nucleotide binding; sphingolipid transporter activity; transporter activity; xenobiotic-transporting ATPase activity
Biological Process: daunorubicin transport; drug export; multidrug transport; phospholipid efflux; plasma membrane long-chain fatty acid transport; positive regulation of cell migration; response to drug; response to oxidative stress; transmembrane transport; transport; xenobiotic transport
Alt. Names/Synonyms: Abcc1; Abcc1a; Abcc1b; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; Leukotriene C(4) transporter; LTC4 transporter; Mdrap; Mrp; Mrp1; Multidrug resistance-associated protein 1; multiple drug resistance-associated protein
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.