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Protein Page:
hnRNP M (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
hnRNP M Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Nucleolus; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: extracellular matrix; integral to plasma membrane; membrane; nuclear matrix; nucleoplasm; paraspeckles; spliceosome
Molecular Function: protein binding; protein domain specific binding
Biological Process: alternative nuclear mRNA splicing, via spliceosome; fibroblast growth factor receptor signaling pathway; gene expression; nuclear mRNA splicing, via spliceosome
Reference #:  P52272 (UniProtKB)
Alt. Names/Synonyms: DKFZp547H118; Heterogeneous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4; hnRNP M; HNRNPM; HNRNPM4; HNRPM; HNRPM4; HTGR1; M4 protein; N-acetylglucosamine receptor 1; NAGR1
Gene Symbols: HNRNPM
Molecular weight: 77,516 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Select Structure to View Below

hnRNP M

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T14‑p AAAEVAAtEIkMEEE
2 3 K17‑sm EVAAtEIkMEEEsGA
0 1 S22‑p EIkMEEEsGAPGVPs
0 4 S29‑p sGAPGVPsGNGAPGP
0 1 K37‑ub GNGAPGPkGEGERPA
0 3 K48‑ac ERPAQNEkRKEKNIK
0 5 K48‑ub ERPAQNEkRKEKNIK
0 264 Y64‑p GGNRFEPyANPtkRY
0 10 T68‑p FEPyANPtkRYRAFI
0 4 K69‑ac EPyANPtkRYRAFIt
0 42 K69‑ub EPyANPtkRYRAFIt
0 2 T76‑p kRYRAFItNIPFDVk
0 1 K83‑ac tNIPFDVkWQsLkDL
0 70 K83‑ub tNIPFDVkWQsLkDL
0 1 K83‑sm tNIPFDVkWQsLkDL
0 17 S86‑p PFDVkWQsLkDLVKE
0 21 K88‑ub DVkWQsLkDLVKEkV
0 1 K88‑sm DVkWQsLkDLVKEkV
0 1 K88‑sc DVkWQsLkDLVKEkV
0 5 K94‑ub LkDLVKEkVGEVtyV
0 1 T99‑p KEkVGEVtyVELLMD
0 1 Y100‑p EkVGEVtyVELLMDA
0 1 K110‑ac LLMDAEGkSRGCAVV
0 54 K110‑ub LLMDAEGkSRGCAVV
0 1 K110‑sm LLMDAEGkSRGCAVV
1 0 K120‑sm GCAVVEFkMEESMkk
0 2 K126‑ub FkMEESMkkAAEVLN
0 1 K126‑sm FkMEESMkkAAEVLN
0 1 K126‑sc FkMEESMkkAAEVLN
0 7 K127‑ub kMEESMkkAAEVLNk
0 1 K127‑sm kMEESMkkAAEVLNk
0 27 K134‑ub kAAEVLNkHsLsGRP
0 1 K134‑ac kAAEVLNkHsLsGRP
0 1 K134‑sm kAAEVLNkHsLsGRP
0 4 S136‑p AEVLNkHsLsGRPLk
0 2 S138‑p VLNkHsLsGRPLkVk
0 3 K143‑ub sLsGRPLkVkEDPDG
1 19 K145‑ub sGRPLkVkEDPDGEH
2 1 K145‑sm sGRPLkVkEDPDGEH
0 1 K159 HARRAMQKVMATTGG
0 11 S204‑p LQAGRLGstVFVANL
0 1 T205‑p QAGRLGstVFVANLD
0 2 Y213‑p VFVANLDykVGWkKL
0 3 K214‑ac FVANLDykVGWkKLk
0 3 K214‑ub FVANLDykVGWkKLk
0 1 K218‑ub LDykVGWkKLkEVFS
0 5 K221‑ub kVGWkKLkEVFSMAG
0 1 K221‑sm kVGWkKLkEVFSMAG
0 16 K239‑ac RADILEDkDGkSRGI
0 29 K239‑ub RADILEDkDGkSRGI
0 1 K239‑sm RADILEDkDGkSRGI
0 70 K242‑ub ILEDkDGkSRGIGTV
0 1 K277‑ac FDRPMHVkMDERALP
1 0 K277‑sm FDRPMHVkMDERALP
0 2 K345‑ub GIGFGINkMGGMEGP
0 8 S365‑p ENMGRFGsGMNMGRI
0 3 S377‑p GRINEILsNALkRGE
0 2 K381‑ac EILsNALkRGEIIAk
0 39 K381‑ub EILsNALkRGEIIAk
0 1 K381‑sm EILsNALkRGEIIAk
0 1 K381‑sc EILsNALkRGEIIAk
0 100 K388‑ub kRGEIIAkQGGGGGG
0 1 K388‑sm kRGEIIAkQGGGGGG
0 44 S397‑p GGGGGGGsVPGIERM
0 9 G412 GPGIDRLGGAGMERM
1 39 S432‑p HGMDRVGsEIERMGL
0 9 S446‑p LVMDRMGsVERMGsG
0 18 S452‑p GsVERMGsGIERMGP
0 2 G453 sVERMGsGIERMGPL
0 2 S467‑p LGLDHMAssIERMGQ
0 9 S468‑p GLDHMAssIERMGQT
0 11 S481‑p QTMERIGsGVERMGA
0 10 R496‑m1 GMGFGLErMAAPIDR
0 1 T507‑p PIDRVGQtIERMGsG
0 23 S513‑p QtIERMGsGVERMGP
0 36 S528‑p AIERMGLsMERMVPA
0 3 G540 VPAGMGAGLERMGPV
0 34 S575‑p LERMGANsLERMGLE
0 33 S588‑p LERMGANsLERMGPA
0 27 S618‑p MGGGGGAsFDRAIEM
0 36 S633‑p ERGNFGGsFAGsFGG
0 14 S637‑p FGGsFAGsFGGAGGH
0 14 K651‑ub HAPGVARkACQIFVR
0 1 K651‑sm HAPGVARkACQIFVR
0 1 R658 kACQIFVRNLPFDFt
0 3 T665‑p RNLPFDFtWkMLKDk
1 0 K667‑ac LPFDFtWkMLKDkFN
1 9 K667‑ub LPFDFtWkMLKDkFN
0 1 K667‑sm LPFDFtWkMLKDkFN
0 4 K672‑ac tWkMLKDkFNECGHV
0 10 K672‑ub tWkMLKDkFNECGHV
0 1 K672‑sm tWkMLKDkFNECGHV
0 47 Y681‑p NECGHVLyADIkMEN
0 2 K685‑ac HVLyADIkMENGkSk
0 2 K685‑ub HVLyADIkMENGkSk
1 1 K685‑sm HVLyADIkMENGkSk
0 1 K690‑ub DIkMENGkSkGCGVV
0 4 K692‑ub kMENGkSkGCGVVkF
0 57 K698‑ac SkGCGVVkFEsPEVA
0 54 K698‑ub SkGCGVVkFEsPEVA
1 2 K698‑sm SkGCGVVkFEsPEVA
0 38 S701‑p CGVVkFEsPEVAERA
0 9 K716‑ub CRMMNGMkLSGREID
0 1 K716‑sm CRMMNGMkLSGREID
  hnRNP M iso2  
T14 AAAEVAATEIKMEEE
K17 EVAATEIKMEEESGA
S22 EIKMEEESGAPGVPS
S29 SGAPGVPSGNGAPGP
K37 GNGAPGPKGEGERPA
K48 ERPAQNEKRKEKNIK
K48 ERPAQNEKRKEKNIK
Y64 GGNRFEPYANPTKRY
T68 FEPYANPTKRYRAFI
K69 EPYANPTKRYRAFIT
K69 EPYANPTKRYRAFIT
T76 KRYRAFITNIPFDVK
K83 TNIPFDVKWQSLKDL
K83 TNIPFDVKWQSLKDL
K83 TNIPFDVKWQSLKDL
S86 PFDVKWQSLKDLVKE
K88 DVKWQSLKDLVKEKV
K88 DVKWQSLKDLVKEKV
K88 DVKWQSLKDLVKEKV
K94 LKDLVKEKVGEVTYV
T99 KEKVGEVTYVELLMD
Y100 EKVGEVTYVELLMDA
K110 LLMDAEGKSRGCAVV
K110 LLMDAEGKSRGCAVV
K110 LLMDAEGKSRGCAVV
K120 GCAVVEFKMEESMKK
K126 FKMEESMKKAAEVLN
K126 FKMEESMKKAAEVLN
K126 FKMEESMKKAAEVLN
K127 KMEESMKKAAEVLNK
K127 KMEESMKKAAEVLNK
K134 KAAEVLNKHSLSGRP
K134 KAAEVLNKHSLSGRP
K134 KAAEVLNKHSLSGRP
S136 AEVLNKHSLSGRPLK
S138 VLNKHSLSGRPLKVK
K143 SLSGRPLKVKEDPDG
K145 SGRPLKVKEDPDGEH
K145 SGRPLKVKEDPDGEH
K159‑ub HARRAMQkAGRLGST
S165 QkAGRLGSTVFVANL
T166 kAGRLGSTVFVANLD
Y174 VFVANLDYKVGWKKL
K175 FVANLDYKVGWKKLK
K175 FVANLDYKVGWKKLK
K179 LDYKVGWKKLKEVFS
K182 KVGWKKLKEVFSMAG
K182 KVGWKKLKEVFSMAG
K200 RADILEDKDGKSRGI
K200 RADILEDKDGKSRGI
K200 RADILEDKDGKSRGI
K203 ILEDKDGKSRGIGTV
K238 FDRPMHVKMDERALP
K238 FDRPMHVKMDERALP
K306 GIGFGINKMGGMEGP
S326 ENMGRFGSGMNMGRI
S338 GRINEILSNALKRGE
K342 EILSNALKRGEIIAK
K342 EILSNALKRGEIIAK
K342 EILSNALKRGEIIAK
K342 EILSNALKRGEIIAK
K349 KRGEIIAKQGGGGGG
K349 KRGEIIAKQGGGGGG
S358 GGGGGGGSVPGIERM
G373 GPGIDRLGGAGMERM
S393 HGMDRVGSEIERMGL
S407 LVMDRMGSVERMGSG
S413 GSVERMGSGIERMGP
G414 SVERMGSGIERMGPL
S428 LGLDHMASSIERMGQ
S429 GLDHMASSIERMGQT
S442 QTMERIGSGVERMGA
R457 GMGFGLERMAAPIDR
T468 PIDRVGQTIERMGSG
S474 QTIERMGSGVERMGP
S489 AIERMGLSMERMVPA
G501 VPAGMGAGLERMGPV
S536 LERMGANSLERMGLE
S549 LERMGANSLERMGPA
S579 MGGGGGASFDRAIEM
S594 ERGNFGGSFAGSFGG
S598 FGGSFAGSFGGAGGH
K612 HAPGVARKACQIFVR
K612 HAPGVARKACQIFVR
R619 KACQIFVRNLPFDFT
T626 RNLPFDFTWKMLKDK
K628 LPFDFTWKMLKDKFN
K628 LPFDFTWKMLKDKFN
K628 LPFDFTWKMLKDKFN
K633 TWKMLKDKFNECGHV
K633 TWKMLKDKFNECGHV
K633 TWKMLKDKFNECGHV
Y642 NECGHVLYADIKMEN
K646 HVLYADIKMENGKSK
K646 HVLYADIKMENGKSK
K646 HVLYADIKMENGKSK
K651 DIKMENGKSKGCGVV
K653 KMENGKSKGCGVVKF
K659 SKGCGVVKFESPEVA
K659 SKGCGVVKFESPEVA
K659 SKGCGVVKFESPEVA
S662 CGVVKFESPEVAERA
K677 CRMMNGMKLSGREID
K677 CRMMNGMKLSGREID
  mouse

 
T14 AAAEVAATEPKMEEE
K17 EVAATEPKMEEESGA
S22 EPKMEEESGAPCVPS
S29 SGAPCVPSGNGAPGP
K37 GNGAPGPKGEERPTQ
K47 ERPTQNEKRKEKNIK
K47 ERPTQNEKRKEKNIK
Y63‑p GGNRFEPySNPTkRY
T67 FEPySNPTkRYRAFI
K68 EPySNPTKRYRAFIT
K68‑ub EPySNPTkRYRAFIT
T75 kRYRAFITNIPFDVk
K82 TNIPFDVKWQsLkDL
K82‑ub TNIPFDVkWQsLkDL
K82 TNIPFDVKWQsLkDL
S85‑p PFDVkWQsLkDLVKE
K87‑ub DVkWQsLkDLVKEKV
K87 DVkWQsLKDLVKEKV
K87 DVkWQsLKDLVKEKV
K93 LkDLVKEKVGEVTYV
T98 KEKVGEVTYVELLMD
Y99 EKVGEVTYVELLMDA
K109 LLMDAEGKSRGCAVV
K109 LLMDAEGKSRGCAVV
K109 LLMDAEGKSRGCAVV
K119 GCAVVEFKMEESMKK
K125 FKMEESMKKAAEVLN
K125 FKMEESMKKAAEVLN
K125 FKMEESMKKAAEVLN
K126 KMEESMKKAAEVLNk
K126 KMEESMKKAAEVLNk
K133‑ub KAAEVLNkHsLsGRP
K133 KAAEVLNKHsLsGRP
K133 KAAEVLNKHsLsGRP
S135‑p AEVLNkHsLsGRPLK
S137‑p VLNkHsLsGRPLKVK
K142 sLsGRPLKVKEDPDG
K144 sGRPLKVKEDPDGEH
K144 sGRPLKVKEDPDGEH
K158 HARRAMQKVMATTGG
S203‑p LQAGRLGsTVFVANL
T204 QAGRLGsTVFVANLD
Y212 VFVANLDYKVGWKKL
K213 FVANLDYKVGWKKLK
K213 FVANLDYKVGWKKLK
K217 LDYKVGWKKLKEVFS
K220 KVGWKKLKEVFSMAG
K220 KVGWKKLKEVFSMAG
K238‑ac RADILEDkDGKSRGI
K238 RADILEDKDGKSRGI
K238 RADILEDKDGKSRGI
K241 ILEDkDGKSRGIGIV
K276 FDRPMHVKMDERALP
K276 FDRPMHVKMDERALP
K344 GIGFGINKIGGMEGP
S364‑p ENMGRFGsGMNMGRI
S376‑p GRINEILsNALkRGE
K380 EILsNALKRGEIIAk
K380‑ub EILsNALkRGEIIAk
K380 EILsNALKRGEIIAk
K380 EILsNALKRGEIIAk
K387‑ub kRGEIIAkQGGGGAG
K387 kRGEIIAKQGGGGAG
S396‑p GGGGAGGsVPGIERM
S411‑p GPGIDRIsGAGMERM
S431‑p HGMDRVGsEIERMGL
S445‑p LVMDRMGsVERMGss
S451‑p GsVERMGssIERMGP
S452‑p sVERMGssIERMGPL
S466 LGLDHMASsIERMGQ
S467‑p GLDHMASsIERMGQT
S480‑p QTMERIGsGVERMGA
R495‑m1 GMGFGLErMAAPIDR
T506 PIDRVGQTIERMGsG
S512‑p QTIERMGsGVERMGP
S527‑p AIERMGLsMDRMVPT
S539‑p VPTGMGAsLERMGPV
S574‑p LERMGANsLERMGLE
S587‑p LERMGANsLERMGPA
S617‑p MGGAGGAsFDRAIEM
S632‑p ERGNFGGsFAGsFGG
S636‑p FGGsFAGsFGGAGGH
K650‑ub HAPGVARkACQIFVr
K650 HAPGVARKACQIFVr
R657‑m2 kACQIFVrNLPFDFt
T664‑p rNLPFDFtWKMLKDK
K666 LPFDFtWKMLKDKFN
K666 LPFDFtWKMLKDKFN
K666 LPFDFtWKMLKDKFN
K671 tWKMLKDKFNECGHV
K671 tWKMLKDKFNECGHV
K671 tWKMLKDKFNECGHV
Y680 NECGHVLYADIKMEN
K684 HVLYADIKMENGKSK
K684 HVLYADIKMENGKSK
K684 HVLYADIKMENGKSK
K689 DIKMENGKSKGCGVV
K691 KMENGKSKGCGVVKF
K697 SKGCGVVKFEsPEVA
K697 SKGCGVVKFEsPEVA
K697 SKGCGVVKFEsPEVA
S700‑p CGVVKFEsPEVAERA
K715 CRMMNGMKLSGREID
K715 CRMMNGMKLSGREID
  rat

 
T14 AAAEVAATEPKMEEE
K17 EVAATEPKMEEESGA
S22 EPKMEEESGAPCVPS
S29 SGAPCVPSGNGAPVP
K37 GNGAPVPKGEERPTQ
K47 ERPTQNEKRKEKNIK
K47 ERPTQNEKRKEKNIK
Y63 GGNRFEPYANPTKRY
T67 FEPYANPTKRYRAFI
K68 EPYANPTKRYRAFIT
K68 EPYANPTKRYRAFIT
T75 KRYRAFITNIPFDVK
K82 TNIPFDVKWQSLKDL
K82 TNIPFDVKWQSLKDL
K82 TNIPFDVKWQSLKDL
S85 PFDVKWQSLKDLVKE
K87 DVKWQSLKDLVKEKV
K87 DVKWQSLKDLVKEKV
K87 DVKWQSLKDLVKEKV
K93 LKDLVKEKVGEVTYV
T98 KEKVGEVTYVELLMD
Y99 EKVGEVTYVELLMDA
K109 LLMDAEGKSRGCAVV
K109 LLMDAEGKSRGCAVV
K109 LLMDAEGKSRGCAVV
K119 GCAVVEFKMEESMKK
K125 FKMEESMKKAAEVLN
K125 FKMEESMKKAAEVLN
K125 FKMEESMKKAAEVLN
K126 KMEESMKKAAEVLNK
K126 KMEESMKKAAEVLNK
K133 KAAEVLNKHSLSGRP
K133 KAAEVLNKHSLSGRP
K133 KAAEVLNKHSLSGRP
S135 AEVLNKHSLSGRPLK
S137 VLNKHSLSGRPLKVK
K142 SLSGRPLKVKEDPDG
K144 SGRPLKVKEDPDGEH
K144 SGRPLKVKEDPDGEH
K158 HARRAMQKVMATTGG
S203 LQAGRLGSTVFVANL
T204 QAGRLGSTVFVANLD
Y212 VFVANLDYKVGWKKL
K213 FVANLDYKVGWKKLK
K213 FVANLDYKVGWKKLK
K217 LDYKVGWKKLKEVFS
K220 KVGWKKLKEVFSMAG
K220 KVGWKKLKEVFSMAG
K238‑ac RADILEDkDGKSRGI
K238 RADILEDKDGKSRGI
K238 RADILEDKDGKSRGI
K241 ILEDkDGKSRGIGTV
K276 FDRPMHVKMDERALP
K276 FDRPMHVKMDERALP
K344 GIGFGINKIGGMEGP
S364 ENMGRFGSGMNMGRI
S376 GRINEILSNALKRGE
K380 EILSNALKRGEIIAk
K380 EILSNALKRGEIIAk
K380 EILSNALKRGEIIAk
K380 EILSNALKRGEIIAk
K387‑ub KRGEIIAkQGGGGAG
K387 KRGEIIAKQGGGGAG
S396‑p GGGGAGGsVPGIERM
S411 GPGIDRISGAGMERM
S431‑p HGMDRVGsEIERMGL
S445‑p LVMDRMGsVERMGSG
S451 GsVERMGSGIERMGP
G452 sVERMGSGIERMGPL
S466 LGLDHMASSIERMGQ
S467 GLDHMASSIERMGQT
S480‑p QTMERIGsGVERMGA
R495‑m1 GMGFGLErMAAPIDR
T506 PIDRVGQTIERMGSG
S512 QTIERMGSGVERMGP
S527‑p AIERMGLsMDRMVPT
G539 VPTGMGAGLERMGPV
S574‑p LERMGANsLERMGLE
S587‑p LERMGANsLERMGPA
S617 MGGAGGASFDRAIEM
S632 ERGNFGGSFAGSFGG
S636 FGGSFAGSFGGAGGH
K650 HAPGVARKACQIFVR
K650 HAPGVARKACQIFVR
R657 KACQIFVRNLPFDFT
T664 RNLPFDFTWKMLKDK
K666 LPFDFTWKMLKDKFN
K666 LPFDFTWKMLKDKFN
K666 LPFDFTWKMLKDKFN
K671 TWKMLKDKFNECGHV
K671 TWKMLKDKFNECGHV
K671 TWKMLKDKFNECGHV
Y680 NECGHVLYADIKMEN
K684 HVLYADIKMENGKSK
K684 HVLYADIKMENGKSK
K684 HVLYADIKMENGKSK
K689 DIKMENGKSKGCGVV
K691 KMENGKSKGCGVVkF
K697‑ac SKGCGVVkFEsPEVA
K697 SKGCGVVKFEsPEVA
K697 SKGCGVVKFEsPEVA
S700‑p CGVVkFEsPEVAERA
K715 CRMMNGMKLSGREID
K715 CRMMNGMKLSGREID
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