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Protein Page:
Gelsolin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Gelsolin a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted, signal peptide; Actin-binding; Secreted
Chromosomal Location of Human Ortholog: 9q33
Cellular Component: actin cap; actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytosol; extracellular region; extracellular space; focal adhesion; nucleus; plasma membrane; podosome; sarcoplasm
Molecular Function: actin binding; calcium ion binding; myosin II binding; protein binding; protein domain specific binding
Biological Process: actin filament capping; actin filament polymerization; actin filament severing; cellular protein metabolic process; extracellular matrix disassembly; negative regulation of virion penetration into host cell; phagocytosis, engulfment; positive regulation of actin nucleation; protein destabilization; sequestering of actin monomers; striated muscle atrophy
Disease: Amyloidosis, Finnish Type
Reference #:  P06396 (UniProtKB)
Alt. Names/Synonyms: Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; GELS; Gelsolin; gelsolin (amyloidosis, Finnish type); GSN
Gene Symbols: GSN
Molecular weight: 85,698 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Gelsolin

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S35‑ga ATASRGAsQAGAPQG
0 1 S51‑p VPEARPNsMVVEHPE
1 0 Y86‑p VPVPTNLyGDFFTGD
0 1 K177 GGVASGFKHVVPNEV
0 1 K177 GGVASGFKHVVPNEV
0 1 K193 VQRLFQVKGRRVVRA
0 1 K245‑ac LKATQVSkGIRDNER
0 4 K245 LKATQVSKGIRDNER
0 1 S261‑p GRARVHVsEEGtEPE
0 1 T265‑p VHVsEEGtEPEAMLQ
0 1 K299 AANRKLAKLYKVSNG
0 1 T309 KVSNGAGTMSVSLVA
0 1 K341 LDHGKDGKIFVWKGK
0 1 K360 EERKAALKTASDFIT
0 2 K360‑ub EERKAALkTASDFIT
0 1 K368 TASDFITKMDYPkQT
0 7 K368‑ub TASDFITkMDYPkQT
0 2 K373‑ub ITkMDYPkQTQVSVL
0 3 T386‑p VLPEGGEtPLFkQFF
0 7 K390‑ac GGEtPLFkQFFKNWR
0 1 K394 PLFkQFFKNWRDPDQ
0 1 S408‑p QTDGLGLsyLSSHIA
1 0 Y409‑p TDGLGLsyLSSHIAN
0 1 T431‑ga AATLHTStAMAAQHG
2 1 Y465‑p VPVDPATyGQFYGGD
0 1 S473‑p GQFYGGDsYIILyNy
0 1 Y478‑p GDsYIILyNyRHGGR
0 1 Y480‑p sYIILyNyRHGGRQG
0 1 S537‑p KEPAHLMsLFGGKPM
0 1 K548 GKPMIIYKGGTSREG
0 1 S562 GGQTAPASTRLFQVR
0 1 K584 RAVEVLPKAGALNsN
0 2 K584‑ub RAVEVLPkAGALNsN
0 1 S590‑p PkAGALNsNDAFVLK
0 2 K597 sNDAFVLKTPSAAyL
1 32 Y603‑p LKTPSAAyLWVGTGA
0 1 S611‑p LWVGTGAsEAEKTGA
0 1 R623 TGAQELLRVLRAQPV
0 3 S636‑p PVQVAEGsEPDGFWE
0 1 K648‑ac FWEALGGkAAyRTsP
1 0 Y651‑p ALGGkAAyRTsPRLK
0 1 S654‑p GkAAyRTsPRLKDKK
0 1 K728‑ac TEALTSAkRYIETDP
0 1 K728‑ub TEALTSAkRYIETDP
0 2 T742‑p PANRDRRtPITVVKQ
  Gelsolin iso2  
- gap
- gap
Y35 VPVPTNLYGDFFTGD
K126 GGVASGFKHVVPNEV
K126 GGVASGFKHVVPNEV
K142 VQRLFQVKGRRVVRA
K194 LKATQVSKGIRDNER
K194 LKATQVSKGIRDNER
S210 GRARVHVSEEGTEPE
T214 VHVSEEGTEPEAMLQ
K248 AANRKLAKLYKVSNG
T258 KVSNGAGTMSVSLVA
K290 LDHGKDGKIFVWKGK
K309 EERKAALKTASDFIT
K309 EERKAALKTASDFIT
K317 TASDFITKMDYPKQT
K317 TASDFITKMDYPKQT
K322 ITKMDYPKQTQVSVL
T335 VLPEGGETPLFKQFF
K339 GGETPLFKQFFKNWR
K343 PLFKQFFKNWRDPDQ
S357 QTDGLGLSYLSSHIA
Y358 TDGLGLSYLSSHIAN
T380 AATLHTSTAMAAQHG
Y414 VPVDPATYGQFYGGD
S422 GQFYGGDSYIILYNY
Y427 GDSYIILYNYRHGGR
Y429 SYIILYNYRHGGRQG
S486 KEPAHLMSLFGGKPM
K497 GKPMIIYKGGTSREG
S511 GGQTAPASTRLFQVR
K533 RAVEVLPKAGALNSN
K533 RAVEVLPKAGALNSN
S539 PKAGALNSNDAFVLK
K546 SNDAFVLKTPSAAYL
Y552 LKTPSAAYLWVGTGA
S560 LWVGTGASEAEKTGA
R572 TGAQELLRVLRAQPV
S585 PVQVAEGSEPDGFWE
K597 FWEALGGKAAYRTSP
Y600 ALGGKAAYRTSPRLK
S603 GKAAYRTSPRLKDKK
K677 TEALTSAKRYIETDP
K677 TEALTSAKRYIETDP
T691 PANRDRRTPITVVKQ
  Gelsolin iso3  
- gap
S11 LFCCFPNSMVVEHPE
Y46 VPVPTNLYGDFFTGD
K137 GGVASGFKHVVPNEV
K137 GGVASGFKHVVPNEV
K153 VQRLFQVKGRRVVRA
K205 LKATQVSKGIRDNER
K205 LKATQVSKGIRDNER
S221 GRARVHVSEEGTEPE
T225 VHVSEEGTEPEAMLQ
K259 AANRKLAKLYKVSNG
T269 KVSNGAGTMSVSLVA
K301 LDHGKDGKIFVWKGK
K320 EERKAALKTASDFIT
K320 EERKAALKTASDFIT
K328 TASDFITKMDYPKQT
K328 TASDFITKMDYPKQT
K333 ITKMDYPKQTQVSVL
T346 VLPEGGETPLFKQFF
K350 GGETPLFKQFFKNWR
K354 PLFKQFFKNWRDPDQ
S368 QTDGLGLSYLSSHIA
Y369 TDGLGLSYLSSHIAN
T391 AATLHTSTAMAAQHG
Y425 VPVDPATYGQFYGGD
S433 GQFYGGDSYIILYNY
Y438 GDSYIILYNYRHGGR
Y440 SYIILYNYRHGGRQG
S497 KEPAHLMSLFGGKPM
K508 GKPMIIYKGGTSREG
S522 GGQTAPASTRLFQVR
K544 RAVEVLPKAGALNSN
K544 RAVEVLPKAGALNSN
S550 PKAGALNSNDAFVLK
K557 SNDAFVLKTPSAAYL
Y563 LKTPSAAYLWVGTGA
S571 LWVGTGASEAEKTGA
R583 TGAQELLRVLRAQPV
S596 PVQVAEGSEPDGFWE
K608 FWEALGGKAAYRTSP
Y611 ALGGKAAYRTSPRLK
S614 GKAAYRTSPRLKDKK
K688 TEALTSAKRYIETDP
K688 TEALTSAKRYIETDP
T702 PANRDRRTPITVVKQ
  mouse

 
A33 ATTSRGRAQERAPQS
T49 VSEARPSTMVVEHPE
Y84 VPVPPNLYGDFFTGD
K175 GGVASGFKHVVPNEV
K175‑ub GGVASGFkHVVPNEV
K191‑ub VQRLFQVkGRRVVRA
K243 LKATQVSKGIRDNER
K243‑ub LKATQVSkGIRDNER
S259 GRAQVHVSEEGGEPE
G263 VHVSEEGGEPEAMLQ
K297 AANRRLAKLYKVSNG
S307‑p KVSNGAGsMSVSLVA
K339 LDHGRDGKIFVWKGK
K358 EERKAALKTASDFIS
K358‑ub EERKAALkTASDFIS
K366 TASDFISKMQYPRQT
K366‑ub TASDFISkMQYPRQT
R371 ISkMQYPRQTQVSVL
T384‑p VLPEGGEtPLFKQFF
K388 GGEtPLFKQFFKNWR
K392 PLFKQFFKNWRDPDQ
G406 QTDGPGLGYLSSHIA
Y407 TDGPGLGYLSSHIAN
T429 AATLHTSTAMAAQHG
Y463 VPVDPATYGQFYGGD
S471 GQFYGGDSYIILYNY
Y476 GDSYIILYNYRHGGR
Y478 SYIILYNYRHGGRQG
S535 KEPAHLMSLFGGKPM
K546 GKPMIIYKGGTSRDG
S560‑p GGQTAPAsIRLFQVR
K582 RAVEVMPKSGALNSN
K582‑ub RAVEVMPkSGALNSN
S588 PkSGALNSNDAFVLk
K595‑ub SNDAFVLkTPSAAYL
Y601 LkTPSAAYLWVGAGA
S609 LWVGAGASEAEKTGA
K621 TGAQELLKVLRSQHV
S634‑p HVQVEEGsEPDAFWE
K646 FWEALGGKTAYRTSP
Y649 ALGGKTAYRTSPRLK
S652 GKTAYRTSPRLKDKK
K726 TEALTSAKRYIETDP
K726 TEALTSAKRYIETDP
T740‑p PANRDRRtPITVVRQ
  rat

 
A33 ATASRGRAQERAPQS
T49 VSETRPSTMVVEHPE
Y84 VPVPPNLYGDFFTGD
K175‑ac GGVASGFkHVVPNEV
K175 GGVASGFKHVVPNEV
K191 VQRLFQVKGRRVVRA
K243 LKATQVSKGIRDNER
K243 LKATQVSKGIRDNER
S259 GRAQVHVSEEGSEPE
S263 VHVSEEGSEPEAMLQ
K297‑ac AANRRLAkLYKVSNS
S307 KVSNSGGSMSVSLVA
K339‑ac LDHGRDGkIFVWKGK
K358‑ac DERKAALkTASDFIS
K358 DERKAALKTASDFIS
K366‑ac TASDFISkMQYPRQT
K366‑ub TASDFISkMQYPRQT
R371 ISkMQYPRQTQVSVL
T384 VLPEGGETPLFkQFF
K388‑ac GGETPLFkQFFkNWR
K392‑ac PLFkQFFkNWRDPDQ
S406 QTDGPGLSYLSSHIA
Y407 TDGPGLSYLSSHIAN
T429 AATLHTSTAMAAQHG
Y463 VLVDPATYGQFYGGD
S471 GQFYGGDSYIILYNY
Y476 GDSYIILYNYRHGGR
Y478 SYIILYNYRHGGRQG
S535 KEPAHLMSLFGGKPM
K546‑ac GKPMIIYkGGTSRDG
S560 GGQTTPASTRLFQVR
K582‑ac RAVEVMPkAGALNSN
K582 RAVEVMPKAGALNSN
S588 PkAGALNSNDAFVLK
K595 SNDAFVLKTPSAAYL
Y601 LKTPSAAYLWVGTGA
S609 LWVGTGASDAEKTGA
K621‑ac TGALELLkVLRAQHV
S634 HVQVEEGSEPDGFWE
K646 FWEALGGKTAYRTSP
Y649 ALGGKTAYRTSPRLK
S652 GKTAYRTSPRLKDKK
K726 TEALTSAKRYIETDP
K726 TEALTSAKRYIETDP
T740 PANRDRRTPITVVRQ
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