Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
Gelsolin (human)

Gelsolin a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q33
Cellular Component: actin cap; actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytosol; extracellular region; extracellular space; focal adhesion; nucleus; plasma membrane; podosome; sarcoplasm
Molecular Function: actin binding; calcium ion binding; myosin II binding; protein binding; protein domain specific binding
Biological Process: actin filament capping; actin filament polymerization; actin filament severing; cellular protein metabolic process; extracellular matrix disassembly; negative regulation of virion penetration into host cell; phagocytosis, engulfment; positive regulation of actin nucleation; protein destabilization; sequestering of actin monomers; striated muscle atrophy
Disease: Amyloidosis, Finnish Type
Reference #:  P06396 (UniProtKB)
Alt. Names/Synonyms: Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; GELS; Gelsolin; gelsolin (amyloidosis, Finnish type); GSN
Gene Symbols: GSN
Molecular weight: 85,698 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein