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BID
a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Mitochondrial |
| Chromosomal Location of Human Ortholog: 4q42 |
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Cellular Component: cytoplasm; cytosol; membrane; mitochondrion
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Molecular Function: protein binding; protein heterodimerization activity; ubiquitin protein ligase binding
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Biological Process: apoptotic mitochondrial changes; brain development; caspase activation; organelle ATP synthesis coupled electron transport; positive regulation of apoptosis; positive regulation of protein homooligomerization; positive regulation of protein oligomerization; protein homooligomerization; protein targeting to mitochondrion; regulation of apoptosis; regulation of cell proliferation; regulation of protein oligomerization; release of cytochrome c from mitochondria; response to estradiol stimulus
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Reference #:
Q9JLT6
(UniProtKB)
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Alt. Names/Synonyms: apoptotic death agonist BID; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; BID; desmocollin type 4; p11 BID; p13 BID; p15 BID; p22 BID
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Gene Symbols: Bid
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Molecular weight:
22,249 Da
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Basal Isoelectric point:
4.85
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Death Receptor Signaling
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Inhibition of Apoptosis
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Mitochondrial Control of Apoptosis
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