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Protein Page:
PDX1 (human)

Overview
PDX1 Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7. Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 13q12.1
Cellular Component: cytosol; nuclear speck
Molecular Function: chromatin binding; protein complex binding; protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity; transcription factor binding
Biological Process: central nervous system development; detection of glucose; exocrine pancreas development; generation of precursor metabolites and energy; glucose homeostasis; glucose metabolic process; gut development; insulin secretion; liver development; morphogenesis of embryonic epithelium; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nitric oxide mediated signal transduction; organ morphogenesis; organ regeneration; organ senescence; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of transcription from RNA polymerase II promoter; response to chlorate; response to cytokine stimulus; response to drug; response to glucocorticoid stimulus; response to iron(II) ion; response to leucine; response to nicotine; response to vitamin; response to wounding; smoothened signaling pathway; stem cell differentiation; transcription from RNA polymerase II promoter
Disease: Diabetes Mellitus, Noninsulin-dependent; Diabetes Mellitus, Permanent Neonatal; Maturity-onset Diabetes Of The Young, Type 4; Pancreatic Agenesis 1
Reference #:  P52945 (UniProtKB)
Alt. Names/Synonyms: Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF-1; IPF1; Islet/duodenum homeobox-1; IUF-1; IUF1; MODY4; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox 1; pancreatic-duodenal homeobox factor 1; PDX-1; PDX1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1
Gene Symbols: PDX1
Molecular weight: 30,771 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDX1

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S61‑p, S66‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T11‑p EEQYYAAtQLYKDPC
3 0 S61‑p LGALEQGsPPDIsPY
3 0 S66‑p QGsPPDIsPYEVPPL
1 0 Y68 sPPDIsPYEVPPLAD
1 0 S124 LPFPWMKSTKAHAWK
1 0 T125 PFPWMKSTKAHAWKG
1 0 T151 EENKRTRTAYTRAQL
1 0 G210 KEEDKKRGGGTAVGG
1 0 T213 DKKRGGGTAVGGGGV
1 0 T230 PEQDCAVTSGEELLA
1 0 S231 EQDCAVTSGEELLAL
0 1 P263 AREGRLPPGLSAsPQ
3 2 S268‑p LPPGLSAsPQPSSVA
1 0 S272 LSAsPQPSSVAPRRP
  mouse

 
T11 EEQYYAATQLYKDPC
S61‑p LGSLEQGsPPDIsPY
S66‑p QGsPPDIsPYEVPPL
Y68 sPPDIsPYEVPPLAS
S125 LPFPWMKSTKAHAWK
T126 PFPWMKSTKAHAWKG
T152‑p EENKRTRtAYTRAQL
S211‑p KEEDKKRsSGtPSGG
T214‑p DKKRsSGtPSGGGGG
T231‑p PEQDCAVtsGEELLA
S232‑p EQDCAVtsGEELLAV
S264‑p VREGLLPsGLSVsPQ
S269‑p LPsGLSVsPQPSSIA
S273 LSVsPQPSSIAPLRP
  rat

 
T11 EEQYYAATQLYKDPC
S61 LGTLEQGSPPDIsPy
S66‑p QGSPPDIsPyEVPPL
Y68‑p SPPDIsPyEVPPLAD
S124‑p LPFPWMKstKAHAWK
T125‑p PFPWMKstKAHAWKS
T151 EENKRTRTAYTRAQL
S210 KEEDKKRSSGTTSGG
T213 DKKRSSGTTSGGGGG
T230 PEQDCAVTSGEELLA
S231 EQDCAVTSGEELLAL
S263 AREGRLPSGLSAsPQ
S268‑p LPSGLSAsPQPsSIA
S272‑p LSAsPQPsSIAPLRP
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