a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; EC 22.214.171.124; TKL group; STKR family; Type1 subfamily
Cellular Component: cell soma; dendrite; integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; glycoprotein binding; metal ion binding; protein binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity
Biological Process: BMP signaling pathway; cartilage condensation; chondrocyte development; dorsal/ventral pattern formation; eye development; inflammatory response; limb morphogenesis; ovarian cumulus expansion; ovulation cycle; positive regulation of bone mineralization; positive regulation of cell differentiation; positive regulation of chondrocyte differentiation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; proteoglycan biosynthetic process; retina development in camera-type eye; retinal ganglion cell axon guidance; skeletal development
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.