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Protein Page:
HIST2H3A/C/D (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HIST2H3A/C/D Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1q21.2
Cellular Component: extracellular region; nucleoplasm; nucleosome; nucleus
Molecular Function: histone binding; protein binding
Biological Process: blood coagulation; cellular protein metabolic process; chromatin silencing at rDNA; negative regulation of gene expression, epigenetic; nucleosome assembly; positive regulation of gene expression, epigenetic; RNA-mediated gene silencing
Reference #:  Q71DI3 (UniProtKB)
Alt. Names/Synonyms: H3 histone family, member M; H3 histone, family 2; histone 2, H3c; histone H3.2; histone H3/m; histone H3/o
Gene Symbols: HIST2H3A; HIST2H3C; HIST2H3D
Molecular weight: 15,388 Da
Basal Isoelectric point: 11.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HIST2H3A/C/D

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K5‑m2 ___MARTkQTArksT
1 0 R9‑m2 ARTkQTArksTGGkA
1 45 K10‑ac RTkQTArksTGGkAP
1 1 S11‑p TkQTArksTGGkAPR
0 46 K15‑ac ArksTGGkAPRkQLA
0 42 K19‑ac TGGkAPRkQLATkAA
1 50 K24‑ac PRkQLATkAARksAP
0 3 K24‑ub PRkQLATkAARksAP
0 2 K28‑ub LATkAARksAPATGG
0 10 S29‑p ATkAARksAPATGGV
0 2 K37‑ub APATGGVkKPHRYRP
1 6 T46‑p PHRYRPGtVALREIR
0 8 K57‑ub REIRRYQksTELLIR
0 13 S58‑p EIRRYQksTELLIRK
0 24 K80‑ac REIAQDFktDLRFQS
0 2 K80‑m2 REIAQDFktDLRFQS
0 20 T81‑p EIAQDFktDLRFQSS
0 2 S97‑p VMALQEAsEAyLVGL
0 1 Y100‑p LQEAsEAyLVGLFED
0 1 T108‑p LVGLFEDtNLCAIHA
0 6 K116‑ac NLCAIHAkRVTIMPK
0 2 K116‑ub NLCAIHAkRVTIMPK
11857 : Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb (Pacific Blue(TM) Conjugate)
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