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Protein Page:
ULK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ULK2 Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Autophagy; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; ULK family
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: pre-autophagosomal structure membrane
Molecular Function: protein binding; protein serine/threonine kinase activity
Biological Process: axon extension; protein amino acid autophosphorylation; regulation of autophagy; response to starvation
Reference #:  Q8IYT8 (UniProtKB)
Alt. Names/Synonyms: KIAA0623; Serine/threonine-protein kinase ULK2; ULK2; Unc-51-like kinase 2; unc-51-like kinase 2 (C. elegans); Unc51.2
Gene Symbols: ULK2
Molecular weight: 112,694 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Select Structure to View Below

ULK2

Protein Structure Not Found.


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Sites Implicated In
autophagy, inhibited: S1027‑p
intracellular localization: S1027‑p
molecular association, regulation: S1027‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S104‑p LQAKGTLsEDTIRVF
0 1 K146 LSYANRRKSsVsGIR
0 2 S148‑p YANRRKSsVsGIRIK
0 2 S150‑p NRRKSsVsGIRIKIA
0 1 S235 KNRSLMPSIPRETSP
0 1 S323‑p IQEENLSsPPLGPPN
0 1 Y331‑p PPLGPPNyLQVSKDS
0 1 T425‑p TSTASSGtNVHGSPR
0 3 S430 SGtNVHGSPRSAVVR
0 1 T441 AVVRRSNTSPMGFLR
0 2 S528 LSGARLQSAPTLTDI
0 1 S547 QKLRKQHSDPVCPSH
0 1 S574‑p RPGSLGTsPtKHLGS
0 1 T576‑p GSLGTsPtKHLGSSP
0 1 S581 sPtKHLGSSPRSSDW
0 1 S582 PtKHLGSSPRSSDWF
0 5 S600 PLPTIIGSPTKTTAP
0 1 T602 PTIIGSPTKTTAPFK
0 1 T613 APFKIPKTQASSNLL
0 1 R640 SKDGNEPRECAHCLL
0 1 R653 LLVQGSERQRAEQQS
0 1 R655 VQGSERQRAEQQSKA
0 1 T726 SSKAVLFTVGSPPHS
0 2 S729 AVLFTVGSPPHSAAA
0 1 S733 TVGSPPHSAAAPTCT
0 8 S771‑p SGRVCVGsPPGPGFG
0 1 S779 PPGPGFGSSPPGAEA
0 5 S780 PGPGFGSSPPGAEAA
0 1 T826‑p MEREHTDtLRHLNVM
0 1 T844‑p TECVLDLtAMRGGNP
0 1 K922‑ac TAVKQVVkNLNERYK
0 1 Y1018‑p DIENVHKyKCSIERR
1 0 S1027‑p CSIERRLsALCHSTA
  mouse

 
S104 LQAKGTLSEDTIRVF
K146‑ac LSYANRRkSNVSGIR
N148 YANRRkSNVSGIRIK
S150 NRRkSNVSGIRIKIA
S235 KNRSLMPSIPRETSP
S323 IQEENLSSPPLGPPN
Y331 PPLGPPNYLQVSKDS
T425 ISTASSGTNPHGsPR
S430‑p SGTNPHGsPRSAVVR
T441‑p AVVRRSNtSPMGFLR
S528‑p LLGARLQsAPTLTDI
S547‑p QKLRKQHsDPVCPSH
S574 RPGSLGTSPTKHTGs
T576 GSLGTSPTKHTGssP
S581‑p SPTKHTGssPRNSDW
S582‑p PTKHTGssPRNSDWF
S600‑p PLPTIIGsPtKTTAP
T602‑p PTIIGsPtKTTAPFK
T613‑gl APFKIPKtQASSNLL
R640‑m2 SKDGNDPrECSHCLS
R653‑m2 LSVQGSErHrSEQQQ
R655‑m2 VQGSErHrSEQQQSK
T727‑gl SARAVLFtVGsPPHs
S730‑p AVLFtVGsPPHsATA
S734‑p tVGsPPHsATAPTCT
S772‑p SGRVCVGsPPGPGLG
S780‑p PPGPGLGssPPGAEG
S781‑p PGPGLGssPPGAEGA
T827 MEREHTDTLRHLNMM
T845 TECVLDLTAVRGGNP
K923 MAVKQVVKNLNERYK
Y1019 DVENVHKYKCSIERR
S1028 CSIERRLSALCCSTA
  rat

 
S104 LQAKGTLSEDTIRVF
K146 LSYASRRKSNVSGIR
N148 YASRRKSNVSGIRIK
S150 SRRKSNVSGIRIKIA
S235‑p KNRSLMPsIPRETSP
S323 IQEENLSSPPLGPPN
Y331 PPLGPPNYLQVSKDS
T425 ISTASSGTNPHSSPR
S430 SGTNPHSSPRSAVVR
T441 AVVRRSNTSPMGFLR
S528 LLGARLQSAPTLTDI
S547 QKLRKQHSDPVCPSL
S574 RPGSLGTSPTKHMGS
T576 GSLGTSPTKHMGSSP
S581 SPTKHMGSSPRSSDW
S582 PTKHMGSSPRSSDWF
S600 PLPTIIGSPTKTTAP
T602 PTIIGSPTKTTAPFK
T613 APFKIPKTQASSNLL
R640 SKDGNDPRQCSHCLL
R653 LLVQGSERHRSEQQS
R655 VQGSERHRSEQQSKA
T727 SARAVLFTVGSPPHS
S730 AVLFTVGSPPHSATA
S734 TVGSPPHSATAPTCT
S772 SGRVCVGSPPAPGFG
S780 PPAPGFGSSPPGAEA
S781 PAPGFGSSPPGAEAA
T827 MEREHTDTLRHLNMM
T845 TECVLDLTAVRGGNP
K923 TAVKQVVKNLNERYK
Y1019 DAESVHKYKCSIERR
S1028 CSIERRLSALCCSTA
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