a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore. Mps1 mRNA levels change little throughout the cell cycle, but its protein expression varies during the cell cycle. Overexpression arrests cells in metaphase by activating the checkpoint. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); EC 188.8.131.52; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor); TTK family