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Protein Page:
MAN1 (human)

Overview
MAN1 Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. Defects in LEMD3 are the cause of Buschke-Ollendorff syndrome (BOS); also known as dermatoosteopoikilosis or disseminated dermatofibrosis with osteopoikilosis or dermatofibrosis lenticularis disseminata with osteopoikilosis or osteopathia condensans disseminata. BOS refers to the association of osteopoikilosis with disseminated connective-tissue nevi. Osteopoikilosis is a skeletal dysplasia characterized by a symmetric but unequal distribution of multiple hyperostotic areas in different parts of the skeleton. Both elastic-type nevi (juvenile elastoma) and collagen-type nevi (dermatofibrosis lenticularis disseminata) have been described in BOS. Skin or bony lesions can be absent in some family members, whereas other relatives may have both. Defects in LEMD3 are a cause of melorheostosis (MEL). Melorheostosis is a rare mesenchymal dysplasia and one of the sclerosing bone disorders. It is caused by a developmental error, with a sclerotomal distribution, frequently involving one limb. It may be asymptomatic, but pain, stiffness with limitation of motion, leg-length discrepancy and limb deformity may occur. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope
Chromosomal Location of Human Ortholog: 12q14
Cellular Component: integral to membrane; membrane; nuclear inner membrane
Molecular Function: chromatin DNA binding; protein binding
Biological Process: negative regulation of activin receptor signaling pathway; negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; nuclear membrane organization and biogenesis
Disease: Buschke-ollendorff Syndrome; Melorheostosis, Isolated
Reference #:  Q9Y2U8 (UniProtKB)
Alt. Names/Synonyms: Inner nuclear membrane protein Man1; integral inner nuclear membrane protein; LEM domain containing 3; LEM domain-containing protein 3; LEMD3; MAN1
Gene Symbols: LEMD3
Molecular weight: 99,997 Da
Basal Isoelectric point: 7.32  Predict pI for various phosphorylation states
Select Structure to View Below

MAN1

Protein Structure Not Found.
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