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Protein Page:
CXCL1 (human)

Overview
CXCL1 Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: extracellular region
Molecular Function: CXCR chemokine receptor binding; enzyme activator activity; receptor binding
Biological Process: actin cytoskeleton organization and biogenesis; cell proliferation; chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; negative regulation of cell proliferation; nervous system development; response to lipopolysaccharide; signal transduction
Reference #:  P09341 (UniProtKB)
Alt. Names/Synonyms: C-X-C motif chemokine 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); CXCL1; fibroblast secretory protein; FSP; GRO; GRO-alpha(1-73); GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73); GRO1; GRO1 oncogene (melanoma growth stimulating activity, alpha); GRO1 oncogene (melanoma growth-stimulating activity); GROA; Growth-regulated alpha protein; Melanoma growth stimulatory activity; melanoma growth stimulatory activity alpha; MGSA; MGSA alpha; MGSA-a; NAP-3; Neutrophil-activating protein 3; SCYB1
Gene Symbols: CXCL1
Molecular weight: 11,301 Da
Basal Isoelectric point: 10.46  Predict pI for various phosphorylation states
Select Structure to View Below

CXCL1

Protein Structure Not Found.
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