a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. Note: This description may include information from UniProtKB.
Protein type: CDKL family; CMGC group; Cell cycle regulation; EC 188.8.131.52; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: ATP binding; cyclin-dependent protein kinase activity; kinase activity; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: neuron migration; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of GTPase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of dendrite development