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Protein Page:
CDKL5 (human)

Overview
CDKL5 a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. Note: This description may include information from UniProtKB.
Protein type: CDKL family; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: cytoplasm; dendrite cytoplasm; nucleoplasm; nucleus
Molecular Function: ATP binding; kinase activity; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: neuron migration; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of GTPase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of dendrite development
Disease: Epileptic Encephalopathy, Early Infantile, 2
Reference #:  O76039 (UniProtKB)
Alt. Names/Synonyms: CDKL5; Cyclin-dependent kinase-like 5; ISSX; serine/threonine kinase 9; Serine/threonine-protein kinase 9; STK9
Gene Symbols: CDKL5
Molecular weight: 115,538 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
Select Structure to View Below

CDKL5

Protein Structure Not Found.
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