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Protein Page:
pyrin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
pyrin Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization. Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF). ARFMF is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence. Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF). ADFMF is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine unresponsiveness. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytoplasm; cytosol; microtubule associated complex; nucleus
Molecular Function: actin binding; protein binding
Biological Process: inflammatory response; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; positive regulation of autophagy
Disease: Familial Mediterranean Fever; Familial Mediterranean Fever, Autosomal Dominant
Reference #:  O15553 (UniProtKB)
Alt. Names/Synonyms: FMF; Marenostrin; Mediterranean fever; Mediterranean fever protein; MEF; MEFV; MGC126560; MGC126586; Pyrin; TRIM20
Gene Symbols: MEFV
Molecular weight: 86,444 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
Select Structure to View Below

pyrin

Protein Structure Not Found.
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Sites Implicated In
activity, inhibited: S242‑p
intracellular localization: S208‑p, S209‑p, S242‑p
molecular association, regulation: S208‑p, S209‑p, S242‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S6‑p __MAKTPsDHLLstL
0 2 S11‑p TPsDHLLstLEELVP
0 2 T12‑p PsDHLLstLEELVPY
0 1 S187 PALPGGRSPGPCRAL
3 3 S208‑p VRLRRNAssAGRLQG
2 0 S209‑p RLRRNAssAGRLQGL
0 1 C226 GAPGQKECRPFEVYL
3 5 S242‑p SGKMRPRsLEVTIST
0 1 - gap
0 1 T267‑p LLTLEEKtAANLDsA
0 1 S273‑p KtAANLDsATEPRAR
0 1 - gap
0 1 S363 QDSHERKSPGSLSPQ
0 1 S368 RKSPGSLSPQPLPQC
0 1 K380‑ac PQCKRHLkQVQLLFC
0 1 K431‑ac QKQLEHLkkLRKSGE
0 1 K432‑ac KQLEHLkkLRKSGEE
0 1 M490 SLEDVGQMVGQIRKA
0 1 S575 EKSTKYFSETLRSEM
0 1 R579 KYFSETLRSEMEMFN
0 1 S580 YFSETLRSEMEMFNV
0 1 T672‑p WILGACKtsISRKGN
0 1 S673‑p ILGACKtsISRKGNM
0 1 Y732‑p RVGSISFyNVTARSH
0 1 Y741‑p VTARSHIyTFASCSF
  mouse

 
G6 __MAKTLGDHLLNTL
N11 TLGDHLLNTLEELLP
T12 LGDHLLNTLEELLPY
S188‑p RRTQGTQsPGDKEST
S205 AQLRRNVSSAGRLQG
S206 QLRRNVSSAGRLQGL
S223‑p NAPGRREsKKAEVYV
S241‑p SGKKRPRsLEITTYS
- gap
T303 SMVLDEKTFRNMSSK
S309 KTFRNMSSKTsLIGE
S312‑p RNMSSKTsLIGEERC
S432‑p QGLLARKsCEAQsPQ
S437‑p RKsCEAQsPQSLPQC
K449 PQCPRHMKQVLLLFC
R500 REQLERLREMRGYVE
E501 EQLERLREMRGYVEE
T559‑p WLQELSQtISKVRET
S640‑p EKNMQCFsEMLssEM
S644‑p QCFsEMLssEMAFSA
S645‑p CFsEMLssEMAFSAS
- gap
- gap
- gap
- gap
  rat

 
V6 __MANTRVDHLLNTL
N11 TRVDHLLNTLEELLP
T12 RVDHLLNTLEELLPY
S188 RRTLVTQSPGDKENR
S214 CREAARNSTAMSQGG
T215 REAARNSTAMSQGGE
S224 MSQGGERSRRLKCIC
V240 QERSDPGVLKLPLTQ
K249‑ac KLPLTQKkENPQIQK
T302 SMMLDEETSRNMSSK
S308 ETSRNMSSKISLTRE
S311 RNMSSKISLTREKRC
S433 QSSRAGKSCEAQSPQ
S438 GKSCEAQSPQFLPQC
K450 PQCPRHMKQVQLLFC
R501 RKQLERLREMRGYVE
E502 KQLERLREMRGYVEE
T560 WLQELVQTIGKVRET
S641 EKNMQRFSEMLGSEM
G645 QRFSEMLGSEMAFSA
S646 RFSEMLGSEMAFSAS
- gap
- gap
- gap
- gap
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