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Protein Page:
PLA2G2E (human)

Overview
PLA2G2E PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids. Belongs to the phospholipase A2 family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Lipid Metabolism - ether lipid; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; EC 3.1.1.4; Secreted, signal peptide; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - alpha-linolenic acid; Phospholipase
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: extracellular region
Molecular Function: calcium ion binding; phospholipase A2 activity
Biological Process: inflammatory response; lipid catabolic process; phosphatidic acid biosynthetic process; phospholipid metabolic process
Reference #:  Q9NZK7 (UniProtKB)
Alt. Names/Synonyms: GIIE sPLA2; Group IIE secretory phospholipase A2; Phosphatidylcholine 2-acylhydrolase 2E; phospholipase A2, group IIE; PLA2G2E; sPLA2-IIE
Gene Symbols: PLA2G2E
Molecular weight: 15,989 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below

PLA2G2E

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y127‑p LGTYNRKyAHyPNKL
0 1 Y130‑p YNRKyAHyPNKLCtG
0 1 T136‑p HyPNKLCtGPtPPC_
0 1 T139‑p NKLCtGPtPPC____
  mouse

 
Y127 LNTYNRKYAHYPNKL
Y130 YNRKYAHYPNKLCTG
T136 HYPNKLCTGPTPPC_
T139 NKLCTGPTPPC____
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