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Protein Page:
ACER3 (human)

Overview
ACER3 Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity. Belongs to the alkaline ceramidase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; Membrane protein, multi-pass; Membrane protein, integral; EC 3.5.1.-; Lipid Metabolism - sphingolipid
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to Golgi membrane
Biological Process: ceramide metabolic process; positive regulation of cell proliferation; sphingolipid biosynthetic process; sphingolipid metabolic process; sphingosine biosynthetic process
Reference #:  Q9NUN7 (UniProtKB)
Alt. Names/Synonyms: ACER3; Alkaline CDase 3; Alkaline ceramidase 3; Alkaline dihydroceramidase SB89; Alkaline phytoceramidase; AlkCDase 3; APHC; FLJ11238; PHCA; phytoceramidase, alkaline
Gene Symbols: ACER3
Molecular weight: 31,552 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
Select Structure to View Below

ACER3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T83‑p GSWCFHMtLKYEMQL
0 1 T124‑p VNYHLLFtLVLFSLI
0 1 T133‑p VLFSLIVtTVYLKVK
  mouse

 
T83 GSWCFHMTLKYEMQL
T124 INYHLLFTLFLYSLT
T133 FLYSLTVTTIYLKVK
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