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Protein Page:
CYBB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYBB Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of granulomatous disease,chronic, X-linked (CGD). A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life- threatening bacterial/fungal infections. Defects in CYBB are a cause of mycobacteriosis atypical X-linked type 2 (AMCBX2). A rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Membrane protein, integral; Mitochondrial; EC 1.-.-.-; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: Xp21.1
Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; mitochondrion; NADPH oxidase complex; phagocytic vesicle membrane; plasma membrane
Molecular Function: electron carrier activity; FAD binding; heme binding; metal ion binding; protein binding; protein heterodimerization activity; superoxide-generating NADPH oxidase activity; voltage-gated ion channel activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; hydrogen peroxide biosynthetic process; inflammatory response; innate immune response; ion transport; respiratory burst; response to reactive oxygen species; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, X-linked; Immunodeficiency 34
Reference #:  P04839 (UniProtKB)
Alt. Names/Synonyms: CGD; CGD91-phox; CY24B; CYBB; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; Cytochrome b558 subunit beta; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; NOX2; p22 phagocyte B-cytochrome; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit
Gene Symbols: CYBB
Molecular weight: 65,336 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Select Structure to View Below

CYBB

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 Y41‑p DIPPKFFytRkLLGS
0 4 T42‑p IPPKFFytRkLLGSA
0 9 K44‑ub PKFFytRkLLGSALA
0 1 Y168‑p KNPEGGLyLAVTLLA
0 2 K294‑ub RFWRSQQkVVITKVV
0 1 K306 KVVTHPFKTIELQMK
0 1 Y324‑p FKMEVGQyIFVKCPK
0 1 K334‑ub VKCPKVSkLEWHPFT
0 1 K373 FNACGCDKQEFQDAW
0 2 K506 KDVITGLKQKTLYGR
0 1 T509 ITGLKQKTLYGRPNW
0 1 K548‑ub ALAETLSkQSISNSE
  mouse

 
Y41 DDGPKYNYTRKLLGS
T42 DGPKYNYTRKLLGSA
K44 PKYNYTRKLLGSALA
Y168 KNPEGGLYVAVTRLA
K294 RFWRSQQKVVITKVV
K306‑ub KVVTHPFkTIELQMK
Y324 FKMEVGQYIFVKCPK
K334 VKCPKVSKLEWHPFT
K373‑ub FNACGCDkQEFQDAW
K506‑ub KDVITGLkQKtLYGR
T509‑p ITGLkQKtLYGRPNW
K548 ALAETLSKQSISNSE
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