Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE). Belongs to the GST superfamily. Alpha family. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Cellular Component: cytoplasm; mitochondrion
Molecular Function: drug binding; glutathione binding; glutathione transferase activity