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Protein Page:
RIPK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RIPK2 a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.10.2; EC 2.7.11.1; Protein kinase, TKL; TKL group; RIPK family
Chromosomal Location of Human Ortholog: 8q21
Cellular Component: cytoplasm; cytoskeleton; cytosol; protein complex; vesicle
Molecular Function: CARD domain binding; LIM domain binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor binding; signal transducer activity
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; adaptive immune response; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; JNK cascade; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein ubiquitination; signal transduction; T cell receptor signaling pathway; toll-like receptor 2 signaling pathway
Reference #:  O43353 (UniProtKB)
Alt. Names/Synonyms: CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD3; CARDIAK; CCK; GIG30; growth-inhibiting gene 30; receptor interacting protein 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; Receptor-interacting protein 2; receptor-interacting serine-threonine kinase 2; Receptor-interacting serine/threonine-protein kinase 2; RICK; RIP-2; RIP-like-interacting CLARP kinase; RIP2; RIPK2
Gene Symbols: RIPK2
Molecular weight: 61,195 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RIPK2

Protein Structure Not Found.
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Download ChimeraX Script


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Sites Implicated In
enzymatic activity, induced: S176‑p, Y474‑p
molecular association, regulation: Y474‑p
protein degradation: Y474‑p
ubiquitination: Y474‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K17‑ub LPTIPYHkLADLRyL
0 1 Y23‑p HkLADLRyLSRGASG
0 4 S168‑p KIADFGLsKWRMMsL
0 3 S174‑p LsKWRMMsLsQsRSs
2 36 S176‑p KWRMMsLsQsRSskS
0 16 S178‑p RMMsLsQsRSskSAP
0 1 S180 MsLsQsRSskSAPEG
0 2 S181‑p sLsQsRSskSAPEGG
0 2 K182‑ub LsQsRSskSAPEGGT
0 2 K203‑ub ENYEPGQkSRASIkH
2 0 K209‑ub QkSRASIkHDIYSYA
0 1 S332 DKKKMELSLNIPVNH
0 1 S345‑p NHGPQEEsCGSSQLH
0 2 S357‑p QLHENSGsPETSRsL
0 1 S361 NSGsPETSRsLPAPQ
0 10 S363‑p GsPETSRsLPAPQDN
0 3 P365 PETSRsLPAPQDNDF
0 357 Y381‑p SRKAQDCyFMKLHHC
0 6 S393‑p HHCPGNHsWDSTISG
0 1 S399 HsWDSTISGSQRAAF
0 1 T411‑p AAFCDHKtTPCSSAI
0 13 T412 AFCDHKtTPCSSAII
0 6 P413 FCDHKtTPCSSAIIN
0 5 S415 DHKtTPCSSAIINPL
0 1 N420 PCSSAIINPLSTAGN
3 1 Y474‑p DLIMKEDyELVSTKP
0 11 S527‑p YPEILVVsRsPsLNL
0 9 S529‑p EILVVsRsPsLNLLQ
0 30 S531‑p LVVsRsPsLNLLQNK
0 8 S539‑p LNLLQNKsM______
4364 : Phospho-RIP2 (Ser176) Antibody
14397 : Phospho-RIP2 (Ser176) (E1I9J) Rabbit mAb
  RIPK2 iso2  
- gap
- gap
S31 KIADFGLSKWRMMSL
S37 LSKWRMMSLSQSRSS
S39 KWRMMSLSQSRSSKS
S41 RMMSLSQSRSSKSAP
S43 MSLSQSRSSKSAPEG
S44 SLSQSRSSKSAPEGG
K45 LSQSRSSKSAPEGGT
K66 ENYEPGQKSRASIKH
K72 QKSRASIKHDIYSYA
S195 DKKKMELSLNIPVNH
S208 NHGPQEESCGSSQLH
S220 QLHENSGSPETSRSL
S224 NSGSPETSRSLPAPQ
S226 GSPETSRSLPAPQDN
P228 PETSRSLPAPQDNDF
Y244 SRKAQDCYFMKLHHC
S256 HHCPGNHSWDSTISG
S262 HSWDSTISGSQRAAF
T274 AAFCDHKTTPCSSAI
T275 AFCDHKTTPCSSAII
P276 FCDHKTTPCSSAIIN
S278 DHKTTPCSSAIINPL
N283 PCSSAIINPLSTAGN
Y337 DLIMKEDYELVSTKP
S390 YPEILVVSRSPSLNL
S392 EILVVSRSPSLNLLQ
S394 LVVSRSPSLNLLQNK
S402 LNLLQNKSM______
  mouse

 
K17 LPPIPYHKLADLHYL
Y23 HKLADLHYLSRGASG
S168 KIADFGLSKWRMMSL
S174 LSKWRMMSLsQsRsy
S176‑p KWRMMSLsQsRsyKS
S178‑p RMMSLsQsRsyKSAP
S180‑p MSLsQsRsyKSAPEG
Y181‑p SLsQsRsyKSAPEGG
K182 LsQsRsyKSAPEGGT
K203‑ub ENYEPGQkSRASVkH
K209‑ub QkSRASVkHDIYSYA
S331‑p CDKKMDLsLNIPANH
S344 NHPPQEESCGSSLLS
S356‑p LLSRNTGsPGPsRSL
S360‑p NTGsPGPsRSLsAPQ
S362 GsPGPsRSLsAPQDK
S364‑p PGPsRSLsAPQDKGF
S380 SGAPQDCSSLKAHHC
S392‑p HHCPGNHsWDGIVsV
S398‑p HsWDGIVsVPPGAAF
A410 AAFCDRRAssCsLAV
S411‑p AFCDRRAssCsLAVI
S412‑p FCDRRAssCsLAVIs
S414‑p DRRAssCsLAVIsPF
S419‑p sCsLAVIsPFLVEKG
Y473 DLIMKEDYELISTKP
S526 YPEVPVLSKAPPSNF
A528 EVPVLSKAPPSNFPQ
P530 PVLSKAPPSNFPQNK
S538‑p SNFPQNKsL______
  rat

 
K17 LPHIPYHKLADLHYL
Y23 HKLADLHYLSRGASG
S168 KIADFGLSKWRMMSL
S174 LSKWRMMSLSQSRSY
S176 KWRMMSLSQSRSYKS
S178 RMMSLSQSRSYKSAP
S180 MSLSQSRSYKSAPEG
Y181 SLSQSRSYKSAPEGG
K182 LSQSRSYKSAPEGGT
K203 ENYEPGQKSRASVKH
K209 QKSRASVKHDIYSYA
S331 CDKKMDLSLNIPASH
S344 SHPPQEESCGSSLLS
S356 LLSRNAGSPGTSRSL
S360 NAGSPGTSRSLSAPQ
S362 GSPGTSRSLSAPQDK
S364 PGTSRSLSAPQDKGF
S380 HGGPQDCSSSKAYHC
S392 YHCPGNHSWDGIISV
S398 HSWDGIISVSQEAAF
A410 AAFCDRRAssCsLTV
S411‑p AFCDRRAssCsLTVI
S412‑p FCDRRAssCsLTVIR
S414‑p DRRAssCsLTVIRPL
R419 sCsLTVIRPLLVEKS
Y473 DLIMKEDYELISTKP
S526 YPEVLLVSRTPSSNV
T528 EVLLVSRTPSSNVLQ
S530 LLVSRTPSSNVLQNK
T538 SNVLQNKTL______
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