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Protein Page:
PRKX (human)

Overview
PRKX Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: Xp22.3
Cellular Component: cytoplasm; nucleus
Molecular Function: cAMP-dependent protein kinase activity; protein binding
Biological Process: angiogenesis; cell adhesion; cell-substrate adhesion; endothelial cell migration; endothelial cell proliferation; myeloid cell differentiation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; regulation of cell adhesion; regulation of cell migration
Reference #:  P51817 (UniProtKB)
Alt. Names/Synonyms: PKX1; PRKX; Protein kinase PKX1; protein kinase, X-linked; Serine/threonine-protein kinase PRKX
Gene Symbols: PRKX
Molecular weight: 40,896 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Select Structure to View Below

PRKX

Protein Structure Not Found.


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