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Protein Page:
CDK14 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDK14 a protein kinase of the CDK family. May play a role in meiosis as well as in neuron differentiation and/or function. Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; Protein kinase, CMGC; Cell cycle regulation; CMGC group; CDK family; TAIRE subfamily; CDK/TAIRE subfamily
Chromosomal Location of Human Ortholog: 7q21-q22
Cellular Component: cytoplasm; cytosol; nucleus; plasma membrane
Molecular Function: ATP binding; cyclin binding; cyclin-dependent protein kinase activity; protein binding
Biological Process: cell division; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation; regulation of cell cycle; Wnt receptor signaling pathway
Reference #:  O94921 (UniProtKB)
Alt. Names/Synonyms: CDK14; Cell division protein kinase 14; cyclin-dependent kinase 14; hPFTAIRE1; KIAA0834; PFTAIRE protein kinase 1; PFTAIRE1; PFTK1; Serine/threonine-protein kinase PFTAIRE-1
Gene Symbols: CDK14
Molecular weight: 53,057 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Select Structure to View Below

CDK14

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 16 S24‑p KKLRRTLsEsFSRIA
0 2 S26‑p LRRTLsEsFSRIALK
0 4 T76‑p KKVRVQRtQsTFDPF
0 54 S78‑p VRVQRtQsTFDPFEK
0 1 T79 RVQRtQsTFDPFEKP
0 26 S95‑p NQVKRVHsENNACIN
0 1 T105‑p NACINFKtsSTGKEs
0 1 S106‑p ACINFKtsSTGKEsP
0 3 S112‑p tsSTGKEsPKVRRHs
0 10 S119‑p sPKVRRHssPssPts
0 5 S120‑p PKVRRHssPssPtsP
0 4 S122‑p VRRHssPssPtsPKF
0 8 S123‑p RRHssPssPtsPKFG
0 4 T125‑p HssPssPtsPKFGKA
0 3 S126‑p ssPssPtsPKFGKAD
0 17 S134‑p PKFGKADsyEKLEKL
0 2 Y135‑p KFGKADsyEKLEKLG
0 2 S145‑p LEKLGEGsyATVYKG
0 30 Y146‑p EKLGEGsyATVYKGK
0 2 K271‑ub ISDTGELkLADFGLA
0 1 S420 ALSHEYFSDLPPRLW
  CDK14 iso2  
- gap
- gap
T58 KKVRVQRTQSTFDPF
S60 VRVQRTQSTFDPFEK
T61 RVQRTQSTFDPFEKP
S77 NQVKRVHSENNACIN
T87 NACINFKTSSTGKES
S88 ACINFKTSSTGKESP
S94 TSSTGKESPKVRRHS
S101 SPKVRRHSSPSSPTS
S102 PKVRRHSSPSSPTSP
S104 VRRHSSPSSPTSPKF
S105 RRHSSPSSPTSPKFG
T107 HSSPSSPTSPKFGKA
S108 SSPSSPTSPKFGKAD
S116 PKFGKADSYEKLEKL
Y117 KFGKADSYEKLEKLG
S127 LEKLGEGSYATVYKG
Y128 EKLGEGSYATVYKGK
K253 ISDTGELKLADFGLA
S402 ALSHEYFSDLPPRLW
  CDK14 iso3  
- gap
- gap
T30 KKVRVQRTQSTFDPF
S32 VRVQRTQSTFDPFEK
T33 RVQRTQSTFDPFEKP
S49 NQVKRVHSENNACIN
T59 NACINFKTSSTGKES
S60 ACINFKTSSTGKESP
S66 TSSTGKESPKVRRHS
S73 SPKVRRHSSPSSPTS
S74 PKVRRHSSPSSPTSP
S76 VRRHSSPSSPTSPKF
S77 RRHSSPSSPTSPKFG
T79 HSSPSSPTSPKFGKA
S80 SSPSSPTSPKFGKAD
S88 PKFGKADSYEKLEKL
Y89 KFGKADSYEKLEKLG
S99 LEKLGEGSYATVYKG
Y100 EKLGEGSYATVYKGK
K225 ISDTGELKLADFGLA
S374 ALSHEYFSDLPPRLW
  mouse

 
S24‑p KKLRRTLsEsFSRIA
S26‑p LRRTLsEsFSRIALK
T76‑p KKVRVQRtQstFDPF
S78‑p VRVQRtQstFDPFEK
T79‑p RVQRtQstFDPFEKP
S95‑p NQVKRVHsENNACIN
S105 NACINFKSSSAGKEs
S106 ACINFKSSSAGKEsP
S112‑p SSSAGKEsPKVRRHs
S119‑p sPKVRRHssPssPts
S120‑p PKVRRHssPssPtsP
S122‑p VRRHssPssPtsPKF
S123‑p RRHssPssPtsPKFG
T125‑p HssPssPtsPKFGKA
S126‑p ssPssPtsPKFGKAD
S134‑p PKFGKADsYEKLEKL
Y135 KFGKADsYEKLEKLG
S145‑p LEKLGEGsyATVYKG
Y146‑p EKLGEGsyATVYKGK
K271‑ub ISDTGELkLADFGLA
S420‑p ALSHEYFsDLPPRLW
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