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Protein Page:
PIK3CA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK3CA Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1- AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with IRS1 in nuclear extracts. Interacts with RUFY3. Interacts with RASD2. Interacts with APPL1. Interacts with HRAS1 and KRAS. Interaction with HRAS1/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2. Belongs to the PI3/PI4-kinase family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 2.7.11.1; Oncoprotein; EC 2.7.1.153; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid
Chromosomal Location of Human Ortholog: 3q26.3
Cellular Component: cytosol; phosphoinositide 3-kinase complex; plasma membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; protein binding
Biological Process: cardiac muscle contraction; endothelial cell migration; epidermal growth factor receptor signaling pathway; leukocyte migration; phosphatidylinositol biosynthetic process; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; platelet activation; regulation of phosphoinositide 3-kinase cascade; T cell costimulation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vasculature development
Disease: Breast Cancer; Colorectal Cancer; Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi; Cowden Syndrome 5; Gastric Cancer; Hepatocellular Carcinoma; Keratosis, Seborrheic; Lung Cancer; Megalencephaly-capillary Malformation-polymicrogyria Syndrome; Nevus, Epidermal; Ovarian Cancer
Reference #:  P42336 (UniProtKB)
Alt. Names/Synonyms: MGC142161; MGC142163; p110-alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K; PI3K-alpha; PIK3CA; PK3CA; PtdIns-3-kinase p110; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha
Gene Symbols: PIK3CA
Molecular weight: 124,284 Da
Basal Isoelectric point: 6.88  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK3CA

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 7 Y246‑p LKLCVLEyQGKYILK
0 1 S275 SQYKYIRSCIMLGRM
0 2 Y294‑p LMAKESLySQLPMDC
0 1 S306‑p MDCFTMPsYSRRIst
0 18 S312‑p PsYSRRIstAtPyMN
0 4 T313‑p sYSRRIstAtPyMNG
0 1 T315‑p SRRIstAtPyMNGET
0 23 Y317‑p RIstAtPyMNGETST
0 1 S332‑p KSLWVINsALRIKIL
0 3 Y355‑p IRDIDKIyVRTGIyH
0 2 Y361‑p IyVRTGIyHGGEPLC
0 2 S507‑p VSREAGFsysHAGLS
0 18 Y508‑p SREAGFsysHAGLSN
0 2 S509‑p REAGFsysHAGLSNR
0 1 Y584‑p RDEVAQMyCLVKDWP
0 1 Y698‑p YCRACGMyLKHLNRQ
0 1 K720 INLTDILKQEKKDET
0 1 S874‑p KGALQFNsHtLHQWL
0 1 T876‑p ALQFNsHtLHQWLKD
0 1 T957‑p ERVPFVLtQDFLIVI
0 1 S1003 NLFINLFSMMLGSGM
0 1 S1008 LFSMMLGSGMPELQS
0 1 Y1021 QSFDDIAYIRKTLAL
0 3 Y1038‑p TEQEALEyFMKQMND
  mouse

 
Y246 LKLCVLEYQGKYILK
S275‑p SQYKYIRsCIMLGRM
Y294 LMAKESLYSQLPIDS
S306 IDSFTMPSYSRRIST
S312 PSYSRRISTATPyMN
T313 SYSRRISTATPyMNG
T315 SRRISTATPyMNGET
Y317‑p RISTATPyMNGETST
S332 KSLWVINSALRIKIL
Y355 IRDIDKIYVRTGIYH
Y361 IYVRTGIYHGGEPLC
S507 VSREAGFSySHTGLS
Y508‑p SREAGFSySHTGLSN
S509 REAGFSySHTGLSNR
Y584 RDEVAQMYCLVKDWP
Y698 YCRACGMYLKHLNRQ
K720‑ub INLTDILkQEKKDET
S874 KGALQFNSHTLHQWL
T876 ALQFNSHTLHQWLKD
T957 ERVPFVLTQDFLIVI
S1003 NLFINLFSMMLGSGM
S1008 LFSMMLGSGMPELQS
Y1021 QSFDDIAYIRKTLAL
Y1038 TEQEALEYFTKQMND
  rat

 
Y246 LKLCVLEYQGKYILK
S275 SQYKYIRSCIMLGRM
Y294 LMAKESLYSQLPIDS
S306 IDSFTMPSYSRRIST
S312 PSYSRRISTATPYMN
T313 SYSRRISTATPYMNG
T315 SRRISTATPYMNGET
Y317 RISTATPYMNGETAT
S332 KSLWVINSALRIKIL
Y355 IRDIDKIYVRTGIYH
Y361 IYVRTGIYHGGEPLC
S507 VSREAGFSYSHTGLS
Y508 SREAGFSYSHTGLSN
S509 REAGFSYSHTGLSNR
Y584 RDEVAQMYCLVKDWP
Y698 YCRACGMYLKHLNRQ
K720 INLTDILKQEKKDET
S874 KGALQFNSHTLHQWL
T876 ALQFNSHTLHQWLKD
T957 ERVPFVLTQDFLIVI
S1003‑p NLFINLFsMMLGsGM
S1008‑p LFsMMLGsGMPELQS
Y1021‑p QSFDDIAyIRKTLAL
Y1038 TEQEALEYFTKQMND
  cow

 
Y246 LKLCVLEYQGKYILK
S275 SQYKYIRSCIMLGRM
Y294 LMAKESLYSQLPMDC
S306 MDCFTMPSYSRRIST
S312 PSYSRRISTATPYMN
T313 SYSRRISTATPYMNG
T315 SRRISTATPYMNGET
Y317 RISTATPYMNGETST
S332 KSLWVINSALRIKIL
Y355 IRDIDKIYVRTGIYH
Y361 IYVRTGIYHGGEPLC
S507 VSREAGFSYSHAGLS
Y508 SREAGFSYSHAGLSN
S509 REAGFSYSHAGLSNR
Y584 RDEVAQMYCLVKDWP
Y698 YCRACGMYLKHLNRQ
K720 INLTDILKQEKKDET
S874 KGALQFNSHTLHQWL
T876 ALQFNSHTLHQWLKD
T957 ERVPFVLTQDFLIVI
S1003 NLFINLFSMMLGSGM
S1008 LFSMMLGSGMPELQS
Y1021 QSFDDIAYIRKTLAL
Y1038 TEQEALEYFMKQMND
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