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Protein Page:
p15-INK4B (human)

p15-INK4B a potent inhibitor that nteracts strongly with CDK4 and CDK6. Potential effector of TGF-beta induced cell cycle arrest. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Inhibitor; Protein kinase, regulatory subunit; Cell cycle regulation
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding
Biological Process: cell cycle arrest; cellular response to extracellular stimulus; cellular response to nutrient; G2/M transition of mitotic cell cycle; megakaryocyte differentiation; mitotic cell cycle checkpoint; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cyclin-dependent protein kinase activity; spleen development
Reference #:  P42772 (UniProtKB)
Gene Symbols: CDKN2B
Molecular weight: 14,722 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

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LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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