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Protein Page:
PEDF (human)

PEDF a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: extracellular matrix; extracellular region; extracellular space
Molecular Function: protein binding; serine-type endopeptidase inhibitor activity
Biological Process: cell proliferation; multicellular organismal development; negative regulation of angiogenesis; positive regulation of neurogenesis
Disease: Osteogenesis Imperfecta, Type Vi
Reference #:  P36955 (UniProtKB)
Alt. Names/Synonyms: Cell proliferation-inducing gene 35 protein; EPC-1; PEDF; PIG35; Pigment epithelium-derived factor; proliferation-inducing protein 35; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Serpin F1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; SERPINF1
Gene Symbols: SERPINF1
Molecular weight: 46,312 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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