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Protein Page:
E2A (mouse)

Overview
E2A a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor
Cellular Component: cytoplasm; nuclear chromatin; nucleus; transcription factor complex
Molecular Function: bHLH transcription factor binding; chromatin binding; DNA binding; mitogen-activated protein kinase kinase kinase binding; PDZ domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: cell development; gastrulation; immunoglobulin V(D)J recombination; lymphocyte differentiation; natural killer cell differentiation; negative regulation of transcription from RNA polymerase II promoter; Peyer's patch development; positive regulation of neuron differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein stabilization; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to drug; response to lipopolysaccharide; T cell differentiation in the thymus; transcription, DNA-dependent
Reference #:  P15806 (UniProtKB)
Alt. Names/Synonyms: A1; AA408400; Alf2; AW209082; bHLHb21; E12; E12/E47; E2A; E47; Immunoglobulin enhancer-binding factor E12/E47; Me2; OTTMUSP00000020636; Pan1; Pan2; TCF-3; Tcf3; Tcfe2a; TFE2; Transcription factor 3; Transcription factor A1; Transcription factor E2-alpha; transcription factor E2a; VDIR
Gene Symbols: Tcf3
Molecular weight: 67,701 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Select Structure to View Below

E2A

Protein Structure Not Found.
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