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Protein Page:
PIK3C3 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK3C3 Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Ubiquitously expressed, with a highest expression in skeletal muscle. Belongs to the PI3/PI4-kinase family. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Motility/polarity/chemotaxis
Cellular Component: late endosome; membrane; midbody; phagocytic vesicle
Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase activity; protein binding; protein kinase activity
Biological Process: autophagic vacuole formation; cellular response to glucose starvation; cellular response to starvation; cytokinesis; early endosome to late endosome transport; endosome organization and biogenesis; macroautophagy; phosphoinositide-mediated signaling; protein amino acid phosphorylation; protein processing; regulation of cytokinesis; regulation of protein secretion
Reference #:  Q6PF93 (UniProtKB)
Alt. Names/Synonyms: 5330434F23Rik; OTTMUSP00000023341; Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphoinositide-3-kinase class 3; phosphoinositide-3-kinase, class 3; PI3-kinase type 3; PI3K type 3; Pik3c3; PK3C3; PtdIns-3-kinase type 3; Vps34
Gene Symbols: Pik3c3
Molecular weight: 101,487 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  Autophagy Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PIK3C3

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S25 NVQLKIGSLEGKREQ
0 1 K96 EWLKLPVKYPDLPRN
0 1 R158 ADGSEPTRtPGRTSs
1 0 T159‑p DGSEPTRtPGRTSsT
1 0 T163 PTRtPGRTSsTLsED
2 0 S164 TRtPGRTSsTLsEDQ
0 2 S165‑p RtPGRTSsTLsEDQM
0 3 S168‑p GRTSsTLsEDQMSRL
0 1 T197‑p VDWLDRLtFREIEMI
0 1 S207‑p EIEMINEsEKRSSNF
0 1 K209 EMINEsEKRSSNFMY
1 0 Y231 VKCDDKEYGIVYYEK
0 1 S243‑p YEKDGDEssPILTSF
1 13 S244‑p EKDGDEssPILTSFE
1 0 S249 EssPILTSFELVKVP
0 1 S261 KVPDPQMSMENLVES
0 1 S268 SMENLVESKHHKLAR
0 1 S276‑p KHHKLARsLRSGPSD
1 1 S282 RsLRSGPSDHDLKPN
0 1 K287 GPSDHDLKPNATTRD
0 1 T305 IIVSYPPTKQLTYEE
1 0 Y310 PPTKQLTYEEQDLVW
0 1 Y321 DLVWKFRYYLTNQEK
0 1 Y322 LVWKFRYYLTNQEKA
0 1 T324 WKFRYYLTNQEKALT
0 1 K346 WDLPQEAKQALELLG
0 1 Y379 TNPTVRRYAVARLRQ
0 1 Y395 DDEDLLMYLLQLVQA
0 1 N448 DSSQIITNPLPPVAS
0 1 A454 TNPLPPVASPPPASK
1 1 S455 NPLPPVASPPPASKA
0 1 T488 SRACKNSTLANYLYW
0 1 S525‑p LNVMRRFsQALLkGD
0 1 K530‑ac RFsQALLkGDkSVRV
0 1 K533‑ac QALLkGDkSVRVMRS
0 2 T625 PAQLFFKTEDGGKYP
0 1 K630 FKTEDGGKYPVIFKH
0 1 Y631 KTEDGGKYPVIFKHG
1 0 T668 ENLDLKLTPYKVLAT
0 1 K778‑ac KPLPPPMkLNKEMVE
0 1 K800‑ac EQYQEFRkQCYTAFL
0 1 Y803 QEFRkQCYTAFLHLR
1 0 K840 LEPDKTVKKVQDKFR
0 1 K845 TVKKVQDKFRLDLSD
0 2 Y884 QIHKFAQYWRK____
13857 : Phospho-PI3 Kinase Class III (Ser249) Antibody
  human

 
S25‑p NVQLKIGsLEGKREQ
K96‑ub EWLKLPVkYPDLPRN
K158‑ub ADGSEPTktPGRtss
T159‑p DGSEPTktPGRtssT
T163‑p PTktPGRtssTLsED
S164‑p TktPGRtssTLsEDQ
S165‑p ktPGRtssTLsEDQM
S168‑p GRtssTLsEDQMSRL
T197 VDWLDRLTFREIEMI
S207 EIEMINESEkRSSNF
K209‑ub EMINESEkRSSNFMY
Y231‑p VKCDDKEyGIVYYEK
S243 YEKDGDESsPILTsF
S244‑p EKDGDESsPILTsFE
S249‑p ESsPILTsFELVKVP
S261‑p KVPDPQMsMENLVEs
S268‑p sMENLVEsKHHKLAR
S276‑p KHHKLARsLRSGPsD
S282‑p RsLRSGPsDHDLkPN
K287‑m1 GPsDHDLkPNAATRD
T305‑p IIVSYPPtKQLTyEE
Y310‑p PPtKQLTyEEQDLVW
Y321‑p DLVWKFRyyLtNQEK
Y322‑p LVWKFRyyLtNQEKA
T324‑p WKFRyyLtNQEKALT
K346‑ub WDLPQEAkQALELLG
Y379‑p TNPTVRRyAVARLRQ
Y395‑p DDEDLLMyLLQLVQA
S448‑p DSSQIITsPLPSVss
S454‑p TsPLPSVssPPPASK
S455‑p sPLPSVssPPPASKT
T488‑p SRACKNStLANYLYW
S525 LNVMRRFSQALLKGD
K530 RFSQALLKGDKSVRV
K533 QALLKGDKSVRVMRS
T625‑p PAQLFFKtEDGGkyP
K630‑ub FKtEDGGkyPVIFKH
Y631‑p KtEDGGkyPVIFKHG
T668‑p ENLDLKLtPYKVLAT
K778 KPLPPPMKLNKEMVE
K800 EQYQEFRKQCyTAFL
Y803‑p QEFRKQCyTAFLHLR
K840‑sm LEPDKTVkKVQDkFR
K845‑sm TVkKVQDkFRLDLSD
Y884‑p QIHKFAQyWRK____
13857 : Phospho-PI3 Kinase Class III (Ser249) Antibody
  rat

 
S25 NVQLKIGSLEGKREQ
K96 EWLKLPVKYPDLPRN
R158 ADGSEPTRTPGRTSS
T159 DGSEPTRTPGRTSST
T163 PTRTPGRTSSTLSED
S164 TRTPGRTSSTLSEDQ
S165 RTPGRTSSTLSEDQM
S168 GRTSSTLSEDQMSRL
T197 VDWLDRLTFREIEMI
S207 EIEMINESEKRSSNF
K209 EMINESEKRSSNFMY
Y231 VKCDDKEYGIVYYEK
S243 YEKDGDESsPILTSF
S244‑p EKDGDESsPILTSFE
S249 ESsPILTSFELVKVP
S261 KVPDPQMSMENLVES
S268 SMENLVESKHHKLAR
S276 KHHKLARSLRSGPSD
S282 RSLRSGPSDHDLKPN
K287 GPSDHDLKPNATTRD
T305 IIVSYPPTKQLTYEE
Y310 PPTKQLTYEEQDLVW
Y321 DLVWKFRYYLTNQEK
Y322 LVWKFRYYLTNQEKA
T324 WKFRYYLTNQEKALT
K346 WDLPQEAKQALELLG
Y379 TNPTVRRYAVARLRQ
Y395 DDEDLLMYLLQLVQA
N448 DSSQIITNPLPPVAS
A454 TNPLPPVASPPPASK
S455 NPLPPVASPPPASKS
T488 SRACKNSTLANYLYW
S525 LNVMRRFSQALLKGD
K530 RFSQALLKGDKSVRV
K533 QALLKGDKSVRVMRS
T625 PAQLFFKTEDGGKYP
K630 FKTEDGGKYPVIFKH
Y631 KTEDGGKYPVIFKHG
T668 ENLDLKLTPYKVLAT
K778 KPLPPPMKLNKEMVE
K800 EQYQEFRKQCYTAFL
Y803 QEFRKQCYTAFLHLR
K840 LEPDKTVKKVQDKFR
K845 TVKKVQDKFRLDLSD
Y884 QIHKFAQYWRK____
13857 : Phospho-PI3 Kinase Class III (Ser249) Antibody
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