Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
RPS26 (human)

RPS26 Defects in RPS26 are the cause of Diamond-Blackfan anemia type 10 (DBA10). It is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S26e family. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; membrane; nucleolus; nucleoplasm; small ribosomal subunit
Molecular Function: mRNA binding; protein binding; structural constituent of ribosome
Biological Process: mRNA catabolic process, nonsense-mediated decay; negative regulation of RNA splicing; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription
Disease: Diamond-blackfan Anemia 10
Reference #:  P62854 (UniProtKB)
Alt. Names/Synonyms: 40S ribosomal protein S26; DBA10; MGC104292; ribosomal protein S26; RPS26; RS26
Gene Symbols: RPS26
Molecular weight: 13,015 Da
Basal Isoelectric point: 11.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene