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Protein Page:
Lamin B2 (human)

Overview
Lamin B2 nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Lamin B2 may be lost during the follicle centre stage of B-cell differentiation in humans. Nuclear lamins are cleaved by caspases during apoptosis. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p13.3
Disease: Epilepsy, Progressive Myoclonic, 9; Lipodystrophy, Partial, Acquired, Susceptibility To
Reference #:  Q03252 (UniProtKB)
Alt. Names/Synonyms: LAMB2; lamin B2; Lamin-B2; LMN2; LMNB2; MGC2721
Gene Symbols: LMNB2
Molecular weight: 69,948 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Lamin B2

Protein Structure Not Found.
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