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Protein Page:
DAPK2 (human)

Overview
DAPK2 an ubiquitously expressed protein kinase of the DAPK family. Activated by Ca(2+)/calmodulin. Contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain. Overexpression induces apoptosis. Expressed at high levels in heart, lung and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; CAMK group; DAPK family
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: cytoplasm
Molecular Function: ATP binding; calmodulin binding; identical protein binding; protein binding; protein serine/threonine kinase activity
Biological Process: anoikis; apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of autophagy
Reference #:  Q9UIK4 (UniProtKB)
Alt. Names/Synonyms: DAP kinase 2; DAP-kinase-related protein 1; DAPK2; death-associated kinase 2; Death-associated protein kinase 2; DRP-1; DRP1; MGC119312
Gene Symbols: DAPK2
Molecular weight: 42,898 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Select Structure to View Below

DAPK2

Protein Structure Not Found.
Download PyMol Script
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Sites Implicated In
apoptosis, altered: S318‑p
apoptosis, inhibited: S318‑p
molecular association, regulation: S318‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S8‑p MFQASMRsPNMEPFK
0 25 S299‑p QAMVRREsVVNLENF
1 3 S318‑p VRRRWKLsFSIVSLC
0 16 S349‑p EDLRNCEsDTEEDIA
0 2 T351 LRNCEsDTEEDIARR
0 18 S367‑p ALHPRRRssTS____
0 18 S368‑p LHPRRRssTS_____
1 1 T369 HPRRRssTS______
0 1 S370 PRRRssTS_______
  mouse

 
S8 MVQASMRSPNMETFK
S299‑p QAMVRREsVVNLENF
S318‑p VRRRWKLsFSIVSLC
S349‑p EDLRNCEsDtEENIA
T351‑p LRNCEsDtEENIARR
S367‑p ALHPRRRssts____
S368‑p LHPRRRssts_____
T369‑p HPRRRssts______
S370‑p PRRRssts_______
  rat

 
- gap
S144‑p QAMVRREsVVNLENF
S163 VRRRWKLSFSIVSLC
S194‑p EDLRNCEsDtEENIA
T196‑p LRNCEsDtEENIARR
S212 ALHPRRRSSTS____
S213 LHPRRRSSTS_____
T214 HPRRRSSTS______
S215 PRRRSSTS_______
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