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Protein Page:
TrkA (human)

Overview
TrkA a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); Oncoprotein; Kinase, protein; EC 2.7.10.1; Protein kinase, TK; TK group; Trk family
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: axon; cell soma; cell surface; cytoplasmic vesicle; dendrite; early endosome; early endosome membrane; endosome; integral to plasma membrane; late endosome; late endosome membrane; plasma membrane; protein complex; receptor complex
Molecular Function: ATP binding; GPI-linked ephrin receptor activity; kinase binding; nerve growth factor binding; nerve growth factor receptor activity; neurotrophin binding; neurotrophin p75 receptor binding; protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; aging; axon guidance; B cell differentiation; circadian rhythm; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; learning and/or memory; mechanoreceptor differentiation; microtubule-based movement; negative regulation of cell proliferation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; olfactory nerve development; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; positive regulation of angiogenesis; positive regulation of GTPase activity; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to activity; response to axon injury; response to drug; response to electrical stimulus; response to ethanol; response to hydrostatic pressure; response to nutrient levels; response to radiation; Sertoli cell development; sympathetic nervous system development
Disease: Insensitivity To Pain, Congenital, With Anhidrosis; Thyroid Carcinoma, Familial Medullary
Reference #:  P04629 (UniProtKB)
Alt. Names/Synonyms: DKFZp781I14186; High affinity nerve growth factor receptor; MTC; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; NTRK1; Oncogene TRK; p140-TrkA; TRK; Trk-A; TRK1; TRK1-transforming tyrosine kinase protein; TRKA; tyrosine kinase receptor A
Gene Symbols: NTRK1
Molecular weight: 87,497 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TrkA

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, induced: Y496‑p, Y791‑p
cell differentiation, altered: Y496‑p, Y701‑p
cell growth, altered: Y496‑p, Y701‑p, Y791‑p
activity, induced: Y757‑p
enzymatic activity, induced: Y496‑p, Y680‑p, Y681‑p, Y791‑p
enzymatic activity, inhibited: Y701‑p
molecular association, regulation: Y496‑p, Y701‑p, Y791‑p
phosphorylation: Y701‑p
protein processing: Y701‑p
protein stabilization: Y701‑p
receptor internalization, altered: Y496‑p, Y680‑p, Y681‑p, Y701‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S123‑p RLSRLNLsFNALESL
18 2 Y496‑p HIIENPQyFSDACVH
0 2 Y591‑p PLLMVFEyMRHGDLN
2 10 Y676‑p FGMSRDIySTDyyRV
9 9 Y680‑p RDIySTDyyRVGGRT
9 5 Y681‑p DIySTDyyRVGGRTM
1 1 Y701‑p MPPESILyRKFTTES
0 2 Y729‑p TYGKQPWyQLSNTEA
3 0 Y757‑p RACPPEVyAIMRGCW
7 2 Y791‑p LAQAPPVyLDVLG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
9141 : Phospho-TrkA (Tyr490) Antibody
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkA iso2  
S123 RLSRLNLSFNALESL
Y490‑p HIIENPQyFSDACVH
Y585 PLLMVFEYMRHGDLN
Y670‑p FGMSRDIySTDyyRV
Y674‑p RDIySTDyyRVGGRT
Y675‑p DIySTDyyRVGGRTM
Y695 MPPESILYRKFTTES
Y723 TYGKQPWYQLSNTEA
Y751‑p RACPPEVyAIMRGCW
Y785‑p LAQAPPVyLDVLG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
9141 : Phospho-TrkA (Tyr490) Antibody
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  mouse

 
S123 RLSHLNLSSNALESL
Y499‑p HIMENPQyFSDTCVH
Y594 PLLMVFEYMRHGDLN
Y679 FGMSRDIYSTDYYRV
Y683 RDIYSTDYYRVGGRT
Y684 DIYSTDYYRVGGRTM
Y704 MPPESILYRKFSTES
Y732 TYGKQPWYQLSNTEA
Y760 RACPPDVYAIMRGCW
Y794 LAQAPPSYLDVLG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  rat

► Hide Isoforms
 
S123 RLSHLNLSSNALESL
Y499‑p HIMENPQyFSDTCVH
Y594 PLLMVFEYMRHGDLN
Y679‑p FGMSRDIySTDyyRV
Y683‑p RDIySTDyyRVGGRT
Y684‑p DIySTDyyRVGGRTM
Y704 MPPESILYRKFSTES
Y732 TYGKQPWYQLSNTEA
Y760‑p RACPPDVyAIMRGCW
Y794‑p LAQAPPSyLDVLG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
9141 : Phospho-TrkA (Tyr490) Antibody
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkA iso2  
S123 RLSHLNLSSNALESL
Y493‑p HIMENPQyFSDTCVH
Y588 PLLMVFEYMRHGDLN
Y673‑p FGMSRDIySTDyyRV
Y677‑p RDIySTDyyRVGGRT
Y678‑p DIySTDyyRVGGRTM
Y698 MPPESILYRKFSTES
Y726 TYGKQPWYQLSNTEA
Y754 RACPPDVYAIMRGCW
Y788 LAQAPPSYLDVLG__
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
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