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Protein Page:
NFE2L1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NFE2L1 Activates erythroid-specific, globin gene expression. Interacts with KEAP1. Belongs to the bZIP family. CNC subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 17q21.3
Cellular Component: cytoplasm; endoplasmic reticulum membrane; integral to membrane; nucleus
Molecular Function: protein binding; transcription cofactor activity; transcription factor activity
Biological Process: anatomical structure morphogenesis; erythrocyte differentiation; heme biosynthetic process; inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  Q14494 (UniProtKB)
Alt. Names/Synonyms: FLJ00380; HBZ17; LCR-F1; Locus control region-factor 1; NF-E2-related factor 1; NF2L1; NFE2-related factor 1; NFE2L1; NRF1; nuclear factor (erythroid-derived 2)-like 1; Nuclear factor erythroid 2-related factor 1; Nuclear factor, erythroid derived 2, like 1; TCF-11; TCF11; Transcription factor 11; transcription factor 11 (basic leucine zipper type); Transcription factor HBZ17; Transcription factor LCR-F1
Gene Symbols: NFE2L1
Molecular weight: 84,704 Da
Basal Isoelectric point: 4.52  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFE2L1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S379‑p
molecular association, regulation: S599‑p
protein degradation: S379‑p
ubiquitination: S379‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3‑p _____MLsLKKYLTE
0 12 K70‑ub DGYGIHPkSIDLDNY
0 1 K199‑ub FDYSHRQkEQDVEkE
0 8 K205‑ub QkEQDVEkELRDGGE
0 1 S285‑p SITEAVPsESEPPAL
1 0 S379‑p SQDFLLFsPEVESLP
0 1 S483 DSGLSLDSSHSPSSL
0 1 S486 LSLDSSHSPSSLSSS
0 1 S492 HSPSSLSSSEGSSSS
0 1 S502‑p GSSSSSSsSSSSSSS
0 1 S505 SSSSsSSSSSSSASS
1 0 S528 EGAVGYSSDSETLDL
1 0 S599‑p PSALKKGsKEKQADF
0 1 K622‑ub EHRARAMkIPFTNDk
0 4 K629‑ub kIPFTNDkIINLPVE
0 1 S643‑p EEFNELLsKYQLSEA
0 1 K644 EFNELLsKYQLSEAQ
0 1 K675‑ub AQNCRKRkLDTILNL
0 10 K713‑ub SLRQMKQkVQSLYQE
0 1 S734‑p DENGRPYsPSQyALQ
0 3 Y738‑p RPYsPSQyALQYAGD
  mouse

 
S3 _____MLSLKKYLTE
K70‑ub DGYGIHPkSIDLDNY
K199 FDYSHRQKEQDVDKE
K205 QKEQDVDKELQDGRE
S256 SIPEAVPSESESPAL
S350 SQDFSLFSPEVESLP
S454‑p DSGLSLDsSHsPSSL
S457‑p LSLDsSHsPSSLSsS
S463‑p HsPSSLSsSEGSSSS
S471 SEGSSSSSSSsSSSS
S474‑p SSSSSSSsSSSSASS
S497‑p EGAVGYSsDSETLDL
S568 PSTLKKGSKEKQADF
K591 EHRARAMKIPFTNDK
K598 KIPFTNDKIINLPVE
S612 EEFNELLSkYQLSEA
K613‑ub EFNELLSkYQLSEAQ
K644 AQNCRKRKLDTILNL
K682 SLRQMKQKVQSLYQE
S703 DEHGRPYSPSQYALQ
Y707 RPYSPSQYALQYAGD
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