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Protein Page:
AIP (human)

Overview
AIP May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA); also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA); also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA); also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane
Molecular Function: protein binding; signal transducer activity; transcription coactivator activity; transcription factor binding; unfolded protein binding
Biological Process: protein maturation via protein folding; protein targeting to mitochondrion
Disease: Pituitary Adenoma, Acth-secreting; Pituitary Adenoma, Growth Hormone-secreting; Pituitary Adenoma, Prolactin-secreting
Reference #:  O00170 (UniProtKB)
Alt. Names/Synonyms: AH receptor-interacting protein; AIP; ARA9; aryl hydrocarbon receptor interacting protein; aryl hydrocarbon receptor-interacting protein; aryl-hydrocarbon receptor interacting protein; Aryl-hydrocarbon receptor-interacting protein; FKBP16; FKBP37; HBV X-associated protein 2; HBV-X associated protein; Immunophilin homolog ARA9; SMTPHN; XAP-2; XAP2
Gene Symbols: AIP
Molecular weight: 37,636 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Select Structure to View Below

AIP

Protein Structure Not Found.
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