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Protein Page:
CCAR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCAR1 Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Apoptosis; RNA splicing
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component: nucleoplasm
Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; protein binding; transcription coactivator activity; transcription corepressor activity
Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of cell migration; positive regulation of cell proliferation
Reference #:  Q8IX12 (UniProtKB)
Alt. Names/Synonyms: CARP-1; CARP1; CCAR1; Cell cycle and apoptosis regulatory protein 1; cell division cycle and apoptosis regulator 1; Cell division cycle and apoptosis regulator protein 1; Death inducer with SAP domain; DIS; MGC44628; RP11-437A18.1
Gene Symbols: CCAR1
Molecular weight: 132,821 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Select Structure to View Below

CCAR1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: Y192‑p, T667‑p
molecular association, regulation: T667‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T151‑p PQKQRVFtGVVTKLH
1 1 Y192‑p RVLVEATyNPNMPFK
0 1 S214‑p TLPNQNQsQTQPLLK
0 4 S287‑p QPPVRIVsQPQPARR
0 1 S302‑p LDPPSRFsGRNDRGD
0 4 S329‑p RERERRRsRERsPQR
0 6 S333‑p RRRsRERsPQRKRsR
0 1 S339‑p RsPQRKRsRERsPRR
0 1 S343‑p RKRsRERsPRRERER
0 1 Y416‑p RPFQLGNyCNFYVMH
0 1 S446‑p PDADHLYsAKVMLMA
0 1 S454‑p AKVMLMAsPsMEDLY
0 9 S456‑p VMLMAsPsMEDLYHK
0 1 K486‑ub QHPARLVkFLVGMKG
0 1 S505‑p MAIGGHWsPSLDGPD
0 4 S626‑p DGEAKEIstPtHWSK
0 26 T627‑p GEAKEIstPtHWSKL
0 5 T629‑p AKEIstPtHWSKLDP
0 1 K637‑ub HWSKLDPkTMKVNDL
0 1 S650‑p DLRKELEsRALSSKG
0 1 K659‑ac ALSSKGLkSQLIARL
1 1 T667‑p SQLIARLtKQLKVEE
0 5 S685‑p EQKELEKsEKEEDED
0 1 K687 KELEKsEKEEDEDDD
0 1 R695 EEDEDDDRKsEDDKE
0 10 S697‑p DEDDDRKsEDDKEEE
0 4 S832‑p PKPKRRKsGDDKDKK
0 6 T861‑p DSKDDDEtEEDNNQD
0 1 Y870‑p EDNNQDEyDPMEAEE
0 1 S992 DEENHEESEsLQEDM
0 1 S994‑p ENHEESEsLQEDMLG
0 1 T1008‑p GNRLLLPtPTVkQES
0 2 K1012‑sm LLPtPTVkQESKDVE
0 3 K1054‑ub VRAEVEQkLQLLEEK
0 1 K1067‑sm EKTDEDEkTILNLEN
0 1 S1078‑p NLENSNKsLsGELRE
0 2 S1080‑p ENSNKsLsGELREVK
0 1 K1088‑ub GELREVKkDLsQLQE
0 1 S1091‑p REVKkDLsQLQENLK
0 1 S1100‑p LQENLKIsENMNLQF
0 1 T1114‑p FENQMNKtIRNLSTV
0 1 K1135‑sm VLKKDNVkNEDKDQK
0 1 N1136 LKKDNVkNEDKDQKS
0 1 S1149‑p KSKENGAsV______
  CCAR1 iso2  
T136 PQKQRVFTGVVTKLH
Y177 RVLVEATYNPNMPFK
S199 TLPNQNQSQTQPLLK
S272 QPPVRIVSQPQPARR
S287 LDPPSRFSGRNDRGD
S314 RERERRRSRERSPQR
S318 RRRSRERSPQRKRSR
S324 RSPQRKRSRERSPRR
S328 RKRSRERSPRRERER
Y401 RPFQLGNYCNFYVMH
S431 PDADHLYSAKVMLMA
S439 AKVMLMASPSMEDLY
S441 VMLMASPSMEDLYHK
K471 QHPARLVKFLVGMKG
S490 MAIGGHWSPSLDGPD
S611 DGEAKEISTPTHWSK
T612 GEAKEISTPTHWSKL
T614 AKEISTPTHWSKLDP
K622 HWSKLDPKTMKVNDL
S635 DLRKELESRALSSKG
K644 ALSSKGLKSQLIARL
T652 SQLIARLTKQLKVEE
S670 EQKELEKSEKEEDED
K672 KELEKSEKEEDEDDD
R680 EEDEDDDRKSEDDKE
S682 DEDDDRKSEDDKEEE
S817 PKPKRRKSGDDKDKK
T846 DSKDDDETEEDNNQD
Y855 EDNNQDEYDPMEAEE
S977 DEENHEESESLQEDM
S979 ENHEESESLQEDMLG
T993 GNRLLLPTPTVKQES
K997 LLPTPTVKQESKDVE
K1039 VRAEVEQKLQLLEEK
K1052 EKTDEDEKTILNLEN
S1063 NLENSNKSLSGELRE
S1065 ENSNKSLSGELREVK
K1073 GELREVKKDLSQLQE
S1076 REVKKDLSQLQENLK
S1085 LQENLKISENMNLQF
T1099 FENQMNKTIRNLSTV
K1120 VLKKDNVKNEDKDQK
N1121 LKKDNVKNEDKDQKS
S1134 KSKENGASV______
  mouse

 
T148 PQKQRVFTGVVTKLH
Y189‑p RVLVEATyNPNMPFK
S211 TLPNQNQSQTQPLLK
S284‑p QPPVRIVsQPQPARR
S299 LDPPSRFSGRNDRGD
S326‑p RDRERRRsRERsPQR
S330‑p RRRsRERsPQRKRSR
S336 RsPQRKRSRERSPRR
S340 RKRSRERSPRRERER
Y413 RPFQLGNYCNFYVMH
S443 PDADHLYSAKVMLMA
S451 AKVMLMASPsMEDLY
S453‑p VMLMASPsMEDLYHK
K483 QHPARLVKFLVGMKG
S502 MAIGGHWSPSLDGPN
A623 DGEVKEIAtPTHWSK
T624‑p GEVKEIAtPTHWSKL
T626 VKEIAtPTHWSKLDP
K634 HWSKLDPKAMKVNDL
S647 DLRKELESRALSSKG
K656 ALSSKGLKSQLIARL
T664 SQLIARLTKQLKIEE
S682‑p EQKELEKsEkEEEDE
K684‑ac KELEKsEkEEEDEDD
K692‑ac EEEDEDDkKsEDDKE
S694‑p EDEDDkKsEDDKEEE
S829‑p PKPKRRKsGDDKDKK
T858‑p DSKDDDEtEEDNNQD
Y867 EDNNQDEYDPMEAEE
S988‑p DDENHEEsEALQEDM
A990 ENHEEsEALQEDMLG
T1004 GNRLLLPTPTIKQES
K1008 LLPTPTIKQESKDGE
K1050 VRAEVEQKLQLLEEK
K1063 EKTDEDGKTILNLEN
S1074 NLENSNKSLsGELRE
S1076‑p ENSNKSLsGELREVK
K1084 GELREVKKDLGQLQE
G1087 REVKKDLGQLQENLE
S1096 LQENLEVSENMNLQF
T1110 FENQLNKTLRNLSTV
K1131 VLKKDNVKsEDRDEK
S1132‑p LKKDNVKsEDRDEKS
G1145 KSKENGSGV______
  rat

 
T148 PQKQRVFTGVVTKLH
Y189 RVLVEATYNPNMPFK
S211 TLPNQNQSQTQPLLK
S284 QPPVRIVSQPQPARR
S299 LDPPSRFSGRNDRGD
S326 RDRERRRSRERSPQR
S330 RRRSRERSPQRKRSR
S336 RSPQRKRSRERSPRR
S340 RKRSRERSPRRERER
Y413 RPFQLGNYCNFYVMH
S443 PDADHLYSAKVMLMA
S451 AKVMLMASPsMEDLY
S453‑p VMLMASPsMEDLYHK
K483 QHPARLVKFLVGMKG
S502 MAIGGHWSPSLDGPN
A623 DGEVKEIAtPTHWSK
T624‑p GEVKEIAtPTHWSKL
T626 VKEIAtPTHWSKLDP
K634 HWSKLDPKAMKVNDL
S647 DLRKELESRALSSKG
K656 ALSSKGLKSQLIARL
T664 SQLIARLTKQLKIEE
S682 EQKELEKSEKEEEDE
K684 KELEKSEKEEEDEDD
K692 EEEDEDDKKSEDDKE
S694 EDEDDKKSEDDKEEE
S829 PKPKRRKSGDDKDKK
T858 DSKDDDETEEDNNQD
Y867 EDNNQDEYDPMEAEE
P989 DGESHDEPESLQGDT
S991 ESHDEPESLQGDTTL
T1006 GNRLLLPTPTVKQES
K1010 LLPTPTVKQESKDGE
K1052 VRAEVEQKLQLLEEK
K1065 EKTDEDGKTILNLEN
S1076 NLENSNKSLSGELRE
S1078 ENSNKSLSGELREVK
K1086 GELREVKKDLGQLQE
G1089 REVKKDLGQLQENLK
S1098 LQENLKVSENMNLQF
T1112 FENQLNKTLRNLSTV
K1133 VLKKDNVKNEDRDQK
N1134 LKKDNVKNEDRDQKS
S1147 KSKENGSSV______
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