a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf, Mos and Cot kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK1 and ERK2. An essential component of MAP kinase signal transduction pathways involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); Kinase, protein; EC 22.214.171.124; STE group; STE7 family
Molecular Function: ATP binding; MAP kinase kinase activity; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein N-terminus binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity; receptor signaling protein tyrosine phosphatase activity
Biological Process: activation of MAPK activity; Bergmann glial cell differentiation; cell cycle arrest; cell motility; cell motility involved in cell locomotion; cerebellar cortex formation; chemotaxis; heart development; keratinocyte differentiation; MAPKKK cascade; negative regulation of cell proliferation; neuron differentiation; peptidyl-tyrosine phosphorylation; positive regulation of axonogenesis; regulation of axon regeneration; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.