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Protein Page:
FANCG (human)

FANCG DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Defects in FANCG are a cause of Fanconi anemia complementation group G (FANCG). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: cytoplasm; mitochondrion; nucleolus; nucleoplasm; plasma membrane
Molecular Function: damaged DNA binding; protein binding
Biological Process: cell cycle checkpoint; DNA repair; mitochondrion organization and biogenesis
Disease: Fanconi Anemia, Complementation Group G; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Reference #:  O15287 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein XRCC9; FAG; FANCG; Fanconi anemia group G protein; Fanconi anemia, complementation group G; Protein FACG; X-ray repair complementing defective repair in Chinese hamster cells 9; X-ray repair, complementing defective, in Chinese hamster, 9; XRCC9
Gene Symbols: FANCG
Molecular weight: 68,554 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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