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Protein Page:
Cbl-c (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Cbl-c Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 19q13.2
Molecular Function: epidermal growth factor receptor binding; phosphotyrosine binding; SH3 domain binding
Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
Reference #:  Q9ULV8 (UniProtKB)
Alt. Names/Synonyms: Cas-Br-M (murine) ecotropic retroviral transforming sequence c; Cas-Br-M (murine) ectropic retroviral transforming sequence c; CBL-3; CBL-SL; CBL3; CBLC; RING finger protein 57; RNF57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C
Gene Symbols: CBLC
Molecular weight: 52,456 Da
Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Select Structure to View Below

Cbl-c

Protein Structure Not Found.
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Sites Implicated In
enzymatic activity, induced: Y341‑p
molecular association, regulation: Y341‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S40‑p VDPRLSVsPPsLRDL
0 1 S43‑p RLSVsPPsLRDLLPR
0 1 S61‑p LLREVAHsRRAAGGG
0 2 S105‑p LPPRGRRsANDELFR
0 1 T223‑p RLFQPWPtLLKNWQL
0 1 Y309‑p QKDGFYLyPDGkTHN
0 1 K313‑ub FYLyPDGkTHNPDLT
2 0 Y341‑p SEEQLQLyWAMDSTF
0 9 Y402‑p GWEAVSIyQFHGQAT
0 3 S461‑p VRLLKGNsPPAALGP
  mouse

 
G40 RDPRMVTGPPSLRDL
S43 RMVTGPPSLRDLLPR
A61 LLGEVAKARREARED
D104 LPPRGKKDVNQDVFR
T222 RLFQPWPTLLRNWQL
F308 QKDGIFLFPDGKKHN
K312 IFLFPDGKKHNPDLT
Y340 SEEQLLLYQAMNSTF
C401 GREAVSICQAQERPT
S484 SVLWEVTSRPRAREE
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