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Protein Page:
ZNF198 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZNF198 a probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. The translocation between FGFR and ZNF198 (8;13)(p11;q12) is oncogenic, causing stem cell leukemia lymphoma syndrome (SCLL), a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The transforming activity of ZNF198-FGFR1 requires the proline-rich domains, but not the ZNF domains, of ZNF198. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 13q11-q12
Cellular Component: cytoplasm; cytosol; PML body
Molecular Function: DNA binding; protein-tyrosine kinase activity; ubiquitin conjugating enzyme binding
Biological Process: cytoskeleton organization and biogenesis; multicellular organismal development; regulation of cell morphogenesis
Reference #:  Q9UBW7 (UniProtKB)
Alt. Names/Synonyms: FIM; fused in myeloproliferative disorder; Fused in myeloproliferative disorders protein; MYM; RAMP; rearranged in an atypical myeloproliferative disorder; Rearranged in atypical myeloproliferative disorder protein; SCLL; Zinc finger MYM-type protein 2; Zinc finger protein 198; zinc finger, MYM-type 2; ZMYM2; ZNF198
Gene Symbols: ZMYM2
Molecular weight: 154,911 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below

ZNF198

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S303‑p, S305‑p, S309‑p
ubiquitination: S303‑p, S305‑p, S309‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S46‑p ANPLVSRsNKFQNSS
0 1 K88‑sm TITFTSSkNEELQGN
0 1 K98‑sm ELQGNDSkITPSSkE
0 1 K104‑ac SkITPSSkELASQKG
0 1 K104‑sm SkITPSSkELASQKG
0 1 S114‑p ASQKGSVsETIVIDD
0 2 P144 NFIERRPPETKNRTN
0 2 S159‑p DVDFSTSsFSRSKVN
0 1 K253‑sm PSLTSQTkTGVGPFN
0 1 K297‑sm ASFPRNQkQPGVDsL
1 3 S303‑p QkQPGVDsLsPVAsL
1 30 S305‑p QPGVDsLsPVAsLPK
1 3 S309‑p DsLsPVAsLPKQIFQ
0 1 K325‑sm SVQQQPTkPVKVTCA
0 1 S362‑p CSTTCLSsFSHkPAP
0 1 K366‑sm CLSsFSHkPAPKKLC
0 1 K417‑sm EDKQNPTkGALNKSR
0 1 K441‑sm IRHEVSFkNMTHKLC
0 1 K491‑sm LVIDGQQkRFCCQSC
0 4 Y502‑p CQSCVSEyKQVGSHP
0 1 K513‑ub GSHPSFLkEVRDHMQ
0 1 S522‑p VRDHMQDsFLMQPEk
0 1 K529‑sm sFLMQPEkYGkLTTC
0 1 K532‑sm MQPEkYGkLTTCTGC
0 4 Y557‑p QCIGPNGyMEPYCSt
0 1 T564‑p yMEPYCStACMNsHK
0 1 S569‑p CStACMNsHKTKYAk
0 1 K576‑sm sHKTKYAkSQSLGII
0 4 Y595‑p KRNSLPQyQATMPDG
0 1 K603‑sm QATMPDGkLyNFCNs
0 2 Y605‑p TMPDGkLyNFCNsSC
0 1 S610‑p kLyNFCNsSCVAKFQ
0 4 S624‑p QALSMQSsPNGQFVA
0 1 K649‑sm CKNSFCSkPEILEWE
0 1 Y671 SKTCSDDYKKLHCIV
0 4 Y680‑p KLHCIVTyCEyCQEE
0 5 Y683‑p CIVTyCEyCQEEKTL
0 1 Y712‑p SEGCKLLyKQDFARR
0 8 Y729‑p LRCVTCNyCSQLCKK
0 1 K757‑sm CSEDCCKkFQDWYYK
0 1 Y800‑p QHCLLRFyCQQNEPN
0 1 Y819 KGPENLHYDQGCQTS
0 2 T831‑p QTSRTKMtGsAPPPs
0 3 S833‑p SRTKMtGsAPPPsPt
0 17 S838‑p tGsAPPPsPtPNKEM
0 5 T840‑p sAPPPsPtPNKEMKN
0 3 Y862‑p LTMTKATyCKPHMQT
0 1 K938 PAAIEELKSKVSSDA
0 1 K938‑sm PAAIEELkSKVSSDA
0 3 S958‑p LTMTDMMsEDEGkTE
1 0 K963‑sm MMsEDEGkTETTNIN
0 2 Y1033‑p PPVFGEEyEEQPRPR
1 7 S1056‑p KAVSGYQsHDDssDN
0 2 S1060‑p GYQsHDDssDNsECS
0 2 S1061‑p YQsHDDssDNsECSF
1 1 S1064‑p HDDssDNsECSFPFK
0 1 K1080‑sm TYGVNAWkHWVKTRQ
0 2 K1099 LLVLDELKSSkSVKL
0 1 K1099‑sm LLVLDELkSSkSVKL
0 1 K1102‑ac LDELkSSkSVKLKED
0 1 T1114‑p KEDLLSHtTAELNYG
0 1 K1159‑ub YLCGSNRkDNIFIDP
0 1 T1218‑p SPVALLNtLFyFNtK
0 1 Y1221‑p ALLNtLFyFNtKYFG
0 1 T1224‑p NtLFyFNtKYFGLKT
0 1 T1253‑p HWKKNPLtMENkACL
0 1 K1257‑sm NPLtMENkACLRYQV
0 24 K1280‑ac EDKITTGkRkHEDDE
0 1 K1280‑ub EDKITTGkRkHEDDE
0 1 K1282‑sm KITTGkRkHEDDEPV
0 1 K1362 LVRVLLVKDIYDKDN
0 21 T1376‑p NYELDEDtD______
  mouse

 
S46 PNPLVSRSSKFQNSS
K88 PITFTSSKNEELQGN
K98 ELQGNDPKILPSSKE
K104 PKILPSSKELAPQKG
K104 PKILPSSKELAPQKG
S114 APQKGSVSETIVIDD
S144‑p NFIERRPsETKNRTN
T159 DVDFSSSTFSRSKVN
K253 PSLTSQTKAGVGPFN
K297 ASFPRNQKQQGVDsL
S303‑p QKQQGVDsLsPVAsL
S305‑p QQGVDsLsPVAsLPK
S309‑p DsLsPVAsLPKQIFQ
K324 PSNQQPTKPVKVTCA
S361 CSTTCLSSFSHKPAP
K365 CLSSFSHKPAPKKLC
K416 EDKQSPAKGALNKSR
K440 IRHEVSFKNMTHKLC
K490 LVVDGQQKRFCCQSC
Y501 CQSCVTEYKQVGSHP
K512 GSHPSFLKEVRDHMQ
S521 VRDHMQDSFLMQPEK
K528 SFLMQPEKYGKLTTC
K531 MQPEKYGKLTTCTGC
Y556 QCIGPNGYMEPYCST
T563 YMEPYCSTACMNSHK
S568 CSTACMNSHKTKYAK
K575 SHKTKYAKSQSLGII
Y594‑p KRNSLPQyQATMPDG
K602 QATMPDGKLYNFCNS
Y604 TMPDGKLYNFCNSSC
S609 KLYNFCNSSCVAKFQ
S623‑p QALSMQSsPNGQFVA
K648 CKNSFCSKPEILEWE
Y670‑p SKTCSDDyKKLHCIV
Y679‑p KLHCIVTyCEyCQEE
Y682‑p CIVTyCEyCQEEKTL
Y711 SEGCKLLYKQDFARR
Y728‑p LRCVTCNyCSQLCKK
K756 CSEDCCKKFQEWYYK
Y799 QHCLLRFYCQQNEPN
Y818‑p KGPENLHyDQGCQTS
T830 QTSRTKMTGSAPPPs
S832 SRTKMTGSAPPPsPT
S837‑p TGSAPPPsPTPNKEM
T839 SAPPPsPTPNKEMKN
Y861‑p LTMTKATyCKPHMQT
K937‑ub PATVEDLkSKVSSDP
K937 PATVEDLKSKVSSDP
T957 LTMTDMMTEEEGKAE
K962 MMTEEEGKAEASNIN
Y1032 PPVFGEEYEEQPRPR
S1055‑p KAVSGYQsHDDssDN
S1059‑p GYQsHDDssDNsECS
S1060‑p YQsHDDssDNsECSF
S1063‑p HDDssDNsECSFPFK
K1079 TYGVNAWKHWVKTRQ
K1098‑ub LLVLDELkSSKSVKL
K1098 LLVLDELKSSKSVKL
K1101 LDELkSSKSVKLKED
T1113 KEDLLSHTTAELNYG
K1158 YLCGSNRKDNIFIDP
T1217 SPVALLNTLFYFNTK
Y1220 ALLNTLFYFNTKYFG
T1223 NTLFYFNTKYFGLKT
T1252 HWKKNPLTMENKACL
K1256 NPLTMENKACLRYQV
K1279‑ac EDKIATGkRKHEDDE
K1279 EDKIATGKRKHEDDE
K1281 KIATGkRKHEDDEPV
K1361‑ac LVRVLLVkDIYDKDN
T1375‑p NYELDEDtD______
  rat

 
S182 PNPLVSRSSKFQNSS
K224 PITFTSSKNEELQGN
K234 ELQGNDPKILPSSKE
K240 PKILPSSKELAPQKG
K240 PKILPSSKELAPQKG
S250 APQKGSVSETIVIDD
S280 NFIERRPSETKNRTN
T295 DVDFSSSTFSRSKVN
K389 PSLTSQTKTGVGPFN
K433 ASFPRNQKQQGVDSL
S439 QKQQGVDSLsPVAsL
S441‑p QQGVDSLsPVAsLPK
S445‑p DSLsPVAsLPKQNFQ
K460 PSNQQPTKPVKVTCA
S497 CSTTCLSSFSHKPAP
K501 CLSSFSHKPAPKKLC
K552 EDKQSPAKGALNKSR
K576 IRHEVSFKNMTHKLC
K626 LVIDGQQKRFCCQSC
Y637 CQSCVSEYKQVGSHP
K648 GSHPSFLKEVRDHMQ
S657 VRDHMQDSFLMQPEK
K664 SFLMQPEKYGKLTTC
K667 MQPEKYGKLTTCTGC
Y692 QCIGPNGYMEPYCST
T699 YMEPYCSTACMNSHK
S704 CSTACMNSHKTKYAK
K711 SHKTKYAKSQSLGII
Y730 KRNSLPQYQATMPDG
K738 QATMPDGKLYNFCNS
Y740 TMPDGKLYNFCNSSC
S745 KLYNFCNSSCVAKFQ
S759 QALSMQSSPNGQFVA
K784 CKNSFCSKPEILEWE
Y806 SRTCSDDYKKLHCIV
Y815 KLHCIVTYCEYCQEE
Y818 CIVTYCEYCQEEKTL
Y847 SEGCKLLYKQDFARR
Y864 LRCVTCNYCSQLCKK
K892 CSEDCCKKFQEWYYK
- gap
- gap
T912 QTSRTKMTGSAPPPS
S914 SRTKMTGSAPPPSPT
S919 TGSAPPPSPTPNKEM
T921 SAPPPSPTPNKEMKN
Y943 LTMTKATYCKPHMQT
K1019 PASVEDLKSKVSSDP
K1019 PASVEDLKSKVSSDP
T1039 LTMTDMMTEEEGKTE
K1044 MMTEEEGKTEASNIN
Y1114 PPVFGEEYEEQPRPR
S1137 KAVSGYQSHDDSSDN
S1141 GYQSHDDSSDNSECS
S1142 YQSHDDSSDNSECSF
S1145 HDDSSDNSECSFPFK
K1161 TYGVNAWKHWVKTRQ
K1180 LLELDELKSSKSVKL
K1180 LLELDELKSSKSVKL
K1183 LDELKSSKSVKLKED
T1195 KEDLLSHTTAELNYG
K1240 YLCGSNRKDNIFIDP
T1299 SPVALLNTLFYFNTK
Y1302 ALLNTLFYFNTKYFG
T1305 NTLFYFNTKYFGLKT
T1334 HWKKNPLTMENKACL
K1338 NPLTMENKACLRYQV
K1361 EDKIATGKRKHEDDE
K1361 EDKIATGKRKHEDDE
K1363 KIATGKRKHEDDEPV
K1443 LVRVLLVKDIYDKDN
T1457‑p NYELDEDtD______
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