Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
Kit (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Kit a receptor tyrosine kinase and a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors. Receptor for stem cell factor. Plays a critical role in hematopoietic stem cell, mast cell, melanocyte and germ cell development. Ligand binding induces autophosphorylation, dimerization and activation, leading to the recruitment and phosphorylation of downstream SH2-containing signaling components including PLC-gamma, PI3 kinase p85, SHP2 and CrkL, linking c-Kit to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, while mutations that constitutively activate c-Kit can lead to hyperplasia and tumorigenesis. Activating mutations cause >90% of gastrointestinal stromal tumors (GIST); successfully treated with inhibitors Gleevec (imatinib, Glivec) and Sutent (Sutinib, SU11248). Activating mutations also induce mastocytosis. Autocrine/paracrine stimulation may drive some lung and other tumors. Loss of expression associated with melanoma progression. Familial loss of function mutations cause piebaldism, with defects in hair and skin pigmentation due to lack of melanocytes. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Kinase, protein; Oncoprotein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; TK group; PDGFR family
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: acrosome; external side of plasma membrane; extracellular space; integral to membrane; intercellular junction; internal side of plasma membrane; mast cell granule; plasma membrane
Molecular Function: ATP binding; cytokine binding; metal ion binding; protease binding; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; stem cell factor receptor activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: actin cytoskeleton reorganization; activation of MAPK activity; activation of MAPKK activity; axon guidance; cytokine and chemokine mediated signaling pathway; dendritic cell cytokine production; detection of mechanical stimulus involved in sensory perception of sound; embryonic hemopoiesis; epidermal growth factor receptor signaling pathway; epithelial cell proliferation; erythrocyte differentiation; fibroblast growth factor receptor signaling pathway; germ cell migration; germ cell programmed cell death; glycosphingolipid metabolic process; gut development; hemopoiesis; immature B cell differentiation; inflammatory response; innate immune response; insulin receptor signaling pathway; lamellipodium biogenesis; lymphoid progenitor cell differentiation; male gonad development; MAPKKK cascade; mast cell chemotaxis; mast cell cytokine production; mast cell degranulation; melanocyte differentiation; myeloid progenitor cell differentiation; negative regulation of programmed cell death; nerve growth factor receptor signaling pathway; ovarian follicle development; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; pigmentation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of JAK-STAT cascade; positive regulation of long-term neuronal synaptic plasticity; positive regulation of MAPKKK cascade; positive regulation of Notch signaling pathway; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of pseudopodium formation; positive regulation of transcription factor activity; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; protein amino acid autophosphorylation; Ras protein signal transduction; regulation of cell proliferation; regulation of cell shape; regulation of pigmentation during development; signal transduction; small GTPase mediated signal transduction; somatic stem cell division; somatic stem cell maintenance; spermatid development; spermatogenesis; stem cell differentiation; stem cell maintenance; T cell differentiation; vascular endothelial growth factor receptor signaling pathway; visual learning
Disease: Gastrointestinal Stromal Tumor; Mast Cell Disease; Piebald Trait; Testicular Germ Cell Tumor
Reference #:  P10721 (UniProtKB)
Alt. Names/Synonyms: C-Kit; CD117; KIT; Mast/stem cell growth factor receptor; PBT; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Gene Symbols: KIT
Molecular weight: 109,865 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Kit

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB


Sites Implicated In
cell adhesion, altered: Y721‑p
cell growth, altered: Y568‑p, Y570‑p
activity, induced: Y568‑p, Y570‑p, Y721‑p
enzymatic activity, induced: Y547‑p, Y553‑p, Y568‑p, Y570‑p
enzymatic activity, inhibited: S741‑p, S746‑p
molecular association, regulation: Y568‑p, Y570‑p, Y900‑p, Y936‑p
phosphorylation: Y568‑p, S741‑p, S746‑p
protein degradation: Y568‑p, Y936‑p
protein stabilization: Y900‑p
receptor internalization, altered: Y568‑p, Y936‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S215‑p FKAVPVVsVsKASYL
0 1 S217‑p AVPVVsVsKASYLLR
0 1 T232‑p EGEEFTVtCTIKDVS
0 1 S240‑p CTIKDVSssVYSTWK
0 1 S241‑p TIKDVSssVYSTWKR
0 1 T274 FNYERQATLTISSAR
0 1 S279 QATLTISSARVNDSG
0 1 T354‑p QWIYMNRtFTDKWED
0 1 Y362‑p FTDKWEDyPKSENES
0 1 T488‑p SAFKHNGtVECKAyN
0 1 Y494‑p GtVECKAyNDVGKTS
1 0 Y547‑p VMILTYKyLQKPMyE
1 0 Y553‑p KyLQKPMyEVQWKVV
12 16 Y568‑p EEINGNNyVyIDPTQ
8 12 Y570‑p INGNNyVyIDPTQLP
0 2 Y578‑p IDPTQLPyDHKWEFP
0 1 K593 RNRLSFGKTLGAGAF
0 1 K602 LGAGAFGKVVEATAy
0 9 Y609‑p KVVEATAyGLIKSDA
0 4 K693 RDSFICSKQEDHAEA
5 24 Y703‑p DHAEAALyKNLLHSK
0 1 S713 LLHSKESSCSDStNE
0 3 T718‑p ESSCSDStNEyMDMK
15 54 Y721‑p CSDStNEyMDMKPGV
0 4 S729‑p MDMKPGVsyVVPTkA
2 29 Y730‑p DMKPGVsyVVPTkAD
0 1 K735‑ub VsyVVPTkADkRRsV
0 1 K738‑ub VVPTkADkRRsVRIG
1 0 S741‑p TkADkRRsVRIGsyI
2 3 S746‑p RRsVRIGsyIERDVT
0 14 Y747‑p RsVRIGsyIERDVTP
0 2 T801‑p AARNILLtHGRITKI
1 1 S821‑p ARDIKNDsNyVVKGN
3 11 Y823‑p DIKNDsNyVVKGNAR
0 1 K884 SKFYKMIKEGFRMLs
1 0 S891‑p KEGFRMLsPEHAPAE
1 2 Y900‑p EHAPAEMyDIMKTCW
0 1 K904 AEMyDIMKTCWDADP
0 1 K926 QIVQLIEKQISEsTN
0 2 S931‑p IEKQISEsTNHIysN
4 104 Y936‑p SEsTNHIysNLANCs
0 3 S937‑p EsTNHIysNLANCsP
0 15 S943‑p ysNLANCsPNRQKPV
1 2 S959‑p DHSVRINsVGSTASS
3073 : Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb
3391 : Phospho-c-Kit (Tyr719) Antibody
  mouse

 
S216 IKAIPVVSVPETSHL
P218 AIPVVSVPETSHLLK
V233 KGDTFTVVCTIKDVS
T241 CTIKDVSTSVNSMWL
S242 TIKDVSTSVNSMWLK
T277‑p FNYERQEtLTISsAR
S282‑p QEtLTISsARVDDSG
T357 QWIYMNRTSANKGKD
Y365 SANKGKDYVKSDNKS
T491 SVFRHNGTVECKASN
S497 GTVECKASNDVGKSS
Y550 VMVLTYKYLQKPMYE
Y556 KYLQKPMYEVQWKVV
Y571‑p EEINGNNyVyIDPTQ
Y573‑p INGNNyVyIDPTQLP
Y581‑p IDPTQLPyDHKWEFP
K596‑ub RNRLSFGkTLGAGAF
K605‑ub LGAGAFGkVVEATAy
Y612‑p kVVEATAyGLIKSDA
K696‑ub RDSFIFSkQEEQAEA
Y706‑p EQAEAALyKNLLHST
S716‑p LLHSTEPsCDSsNEy
S720‑p TEPsCDSsNEyMDMK
Y723‑p sCDSsNEyMDMKPGV
S731‑p MDMKPGVsyVVPTKT
Y732‑p DMKPGVsyVVPTKTD
K737 VsyVVPTKTDKRRSA
K740 VVPTKTDKRRSARID
S743 TKTDKRRSARIDsyI
S748‑p RRSARIDsyIERDVT
Y749‑p RSARIDsyIERDVTP
T803 AARNILLTHGRITKI
S823 ARDIRNDSNyVVKGN
Y825‑p DIRNDSNyVVKGNAR
K886‑ac SKFYKMIkEGFRMVS
S893 kEGFRMVSPEHAPAE
Y902‑p EHAPAEMyDVMkTCW
K906‑ac AEMyDVMkTCWDADP
K928‑ub QVVQLIEkQISDSTK
S933 IEkQISDSTKHIysN
Y938‑p SDSTKHIysNLANCN
S939‑p DSTKHIysNLANCNP
N945 ysNLANCNPNPENPV
S962 DHSVRVNSVGSSASS
3391 : Phospho-c-Kit (Tyr719) Antibody
  rat

 
S215 IKAIPVVSVPETSHL
P217 AIPVVSVPETSHLLK
I232 EGDTFTVICTIKDVS
T240 CTIKDVSTSVDSMWI
S241 TIKDVSTSVDSMWIK
T276 FNYERQETLTISSAR
S281 QETLTISSARVNDSG
T356 QWIYMNRTPTNRGED
Y364 PTNRGEDYVKSDNQS
T490 SVFRHNGTVECKASN
S496 GTVECKASNAVGKSS
Y549 VMVLAYKYLQKPMYE
Y555 KYLQKPMYEVQWKVV
Y570 EEINGNNYVYIDPTQ
Y572 INGNNYVYIDPTQLP
Y580 IDPTQLPYDHKWEFP
K595 RNRLSFGKTLGAGAF
K604 LGAGAFGKVVEATAY
Y611 KVVEATAYGLIKSDA
K695 RDSFIFSKQEEQADA
Y705 EQADAALYKNLLHSK
S715 LLHSKESSCDSSNEY
S719 KESSCDSSNEYMDMK
Y722 SCDSSNEYMDMKPGV
S730 MDMKPGVSYVVPTKT
Y731 DMKPGVSYVVPTKTD
K736 VSYVVPTKTDKRRSA
K739 VVPTKTDKRRSARID
S742 TKTDKRRSARIDsYI
S747‑p RRSARIDsYIERDVT
Y748 RSARIDsYIERDVTP
T802 AARNILLTHGRITKI
S822 ARDIRNDSNYVVKGN
Y824 DIRNDSNYVVKGNAR
K885 SKFYKMIKEGFRMLS
S892 KEGFRMLSPEHAPAA
Y901 EHAPAAMYEVMKTCW
K905 AAMYEVMKTCWDADP
K927 QVVQLIEKQISDSSK
S932 IEKQISDSSKHIYSN
Y937 SDSSKHIYSNLANCN
S938 DSSKHIYSNLANCNP
N944 YSNLANCNPNPENPV
S961‑p DHSVRVNsVGSSTSS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.