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Protein Page:
EAR-2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EAR-2 Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 19p13.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein binding; sequence-specific DNA binding; thyroid hormone receptor activity; transcription factor activity
Biological Process: negative regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter
Reference #:  P10588 (UniProtKB)
Alt. Names/Synonyms: EAR-2; EAR2; ERBA-related gene-2; ERBAL2; NR2F6; Nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; V-erbA-related protein 2
Gene Symbols: NR2F6
Molecular weight: 42,979 Da
Basal Isoelectric point: 7.96  Predict pI for various phosphorylation states
Select Structure to View Below

EAR-2

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S83‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 11 S34‑p AAEDDSAsPPGAAsD
0 2 A39 SAsPPGAAsDAEPGD
0 13 S40‑p AsPPGAAsDAEPGDE
1 0 S83‑p CKSFFKRsIRRNLsY
0 1 S89‑p RsIRRNLsYTCRSNR
0 2 K291‑ub AFQEQVDkLGRLQVD
0 3 K379‑ub FFMRLVGktPIEtLI
0 1 T380‑p FMRLVGktPIEtLIR
0 1 T384‑p VGktPIEtLIRDMLL
0 1 S392‑p LIRDMLLsGSTFNWP
  mouse

 
S35‑p ATEDDSAsPPGAtsD
T40‑p SAsPPGAtsDAEPGD
S41‑p AsPPGAtsDAEPGDE
S84 CKSFFKRSIRRNLSY
S90 RSIRRNLSYTCRSNR
K278‑ub AFQEQVDkLGRLQVD
K366‑ub FFMRLVGkTPIETLI
T367 FMRLVGkTPIETLIR
T371 VGkTPIETLIRDMLL
S379 LIRDMLLSGSTFNWP
  rat

 
S35 ATEDDSASPPGATSD
T40 SASPPGATSDAEPGD
S41 ASPPGATSDAEPGDE
T84 CKSFFKRTIRRNLSY
S90 RTIRRNLSYTCRSNR
K278 AFQEQVDKLGRLQVD
K366 FFMRLVGKTPIETLI
T367 FMRLVGKTPIETLIR
T371 VGKTPIETLIRDMLL
S379 LIRDMLLSGSTFNWP
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