Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
KCNN4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KCNN4 Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: plasma membrane; voltage-gated potassium channel complex
Molecular Function: calcium-activated potassium channel activity; potassium channel activity; protein binding; protein phosphatase binding
Biological Process: calcium ion transport; defense response; positive regulation of T cell receptor signaling pathway; potassium ion transport; stabilization of membrane potential
Reference #:  O15554 (UniProtKB)
Alt. Names/Synonyms: hIKCa1; hKCa4; hSK4; IK1; IKCA1; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCA4; KCNN4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; Putative Gardos channel; SK4; SKCa 4; SKCa4
Gene Symbols: KCNN4
Molecular weight: 47,696 Da
Basal Isoelectric point: 9.87  Predict pI for various phosphorylation states
Select Structure to View Below

KCNN4

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
activity, induced: H358‑p
activity, inhibited: T329‑p, S334‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y199‑p HWFVAKLyMNTHPGR
1 0 S314 YTKEMKESAARVLQE
2 0 T329‑p AWMFYKHtRRKEsHA
3 0 S334‑p KHtRRKEsHAARRHQ
1 0 A350 KLLAAINAFRQVRLK
4 0 H358‑p FRQVRLKhRKLREQV
0 2 S367‑p KLREQVNsMVDISKM
0 3 K394‑ub SSHRALEkQIDtLAG
0 2 T398‑p ALEkQIDtLAGKLDA
  mouse

 
Y197 HWFVAKLYMNTHPGR
S312 YAKEMKESAARLLQE
T327 AWMYYKHTRRKDSRA
S332 KHTRRKDSRAARRHQ
T348 KMLAAIHTFRQVRLK
H356‑p FRQVRLKhRKLREQV
S365 KLREQVNSMVDISKM
K392 SSHRALEKRIDGLAG
G396 ALEKRIDGLAGKLDA
  rat

 
Y197 HWFVAKLYMNTHPGR
S312‑p YAKEMKEsAARLLQE
T327‑p AWMYYKHtRRKDsRA
S332‑p KHtRRKDsRAARRHQ
T348‑p KMLAAIHtFRQVRLK
H356 FRQVRLKHRKLREQV
S365 KLREQVNSMVDISKM
K392 ASHLALEKRIDGLAG
G396 ALEKRIDGLAGKLDA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.