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Protein Page:
ARHGEF7 (human)

Overview
ARHGEF7 a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: cell soma; cytosol; focal adhesion; lamellipodium; neuron projection; protein complex
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein kinase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: ephrin receptor signaling pathway; focal adhesion formation; Golgi organization and biogenesis; lamellipodium biogenesis; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Reference #:  Q14155 (UniProtKB)
Alt. Names/Synonyms: ARHG7; ARHGEF7; Beta-Pix; COOL-1; COOL1; DKFZp686C12170; DKFZp761K1021; guanine nucleotide exchange factor 7; KIAA0142; KIAA0412; Nbla10314; P50; P50BP; p85; P85COOL1; P85SPR; PAK-interacting exchange factor beta; PAK3; PAK3BP; PIXB; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor 7; SH3 domain-containing proline-rich protein
Gene Symbols: ARHGEF7
Molecular weight: 90,012 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ARHGEF7

Protein Structure Not Found.
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