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Protein Page:
NKX2-3 (human)

Overview
NKX2-3 Transcription factor. Belongs to the NK-2 homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 10q24.2
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: CD4-positive, alpha beta T cell differentiation; gland morphogenesis; leukocyte homeostasis; leukocyte migration; lymph node development; macrophage differentiation; odontogenesis of dentine-containing teeth; Peyer's patch development; plasma cell differentiation; positive regulation of transcription from RNA polymerase II promoter; post-embryonic gut morphogenesis; regulation of cell proliferation; spleen development; transcription, DNA-dependent; triacylglycerol metabolic process
Reference #:  Q8TAU0 (UniProtKB)
Alt. Names/Synonyms: CSX3; Homeobox protein NK-2 homolog C; Homeobox protein Nkx-2.3; NK2 transcription factor related, locus 3 (Drosophila); NK2.3; NKX2-3; NKX2.3; NKX23; NKX2C; NKX4-3
Gene Symbols: NKX2-3
Molecular weight: 38,406 Da
Basal Isoelectric point: 7.19  Predict pI for various phosphorylation states
Select Structure to View Below

NKX2-3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S211 KRQRQDKSLELGAHA
0 1 A216 DKSLELGAHAPPPPP
0 1 - gap
0 1 - gap
  mouse

► Hide Isoforms
 
S208‑p KRQRQDKsLELGtHA
T213‑p DKsLELGtHAPPPPP
- gap
- gap
  NKX2-3 iso2  
S208 KRQRQDKSLELGTHA
T213 DKSLELGTHAPPPPP
T376‑p TRRASYCtLGtAGMR
T379‑p ASYCtLGtAGMRHEK
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