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Protein Page:
TLR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TLR1 Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft; membrane; phagocytic vesicle membrane; plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; receptor activity; transmembrane receptor activity
Biological Process: defense response to bacterium; detection of triacylated bacterial lipoprotein; immune response; inflammatory response; innate immune response; macrophage activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; signal transduction; toll-like receptor 1 signaling pathway; toll-like receptor signaling pathway
Disease: Leprosy, Susceptibility To, 5
Reference #:  Q15399 (UniProtKB)
Gene Symbols: TLR1
Molecular weight: 90,291 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TLR1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S44‑p IHVPKDLsQKTtILN
0 2 T48‑p KDLsQKTtILNIsQN
0 1 S53‑p KTtILNIsQNyISEL
0 1 Y56‑p ILNIsQNyISELWTS
0 1 S406 SLQQLDISQNSVSYD
0 1 K416‑m3 SVSYDEKkGDCsWtK
0 1 S420‑p DEKkGDCsWtKSLLS
0 1 T422‑p KkGDCsWtKSLLSLN
0 1 S431‑p SLLSLNMsSNILTDT
0 1 T529‑p GDNPFQCtCELGEFV
0 2 S678‑p RNFVPGKsIVENIIt
0 1 T685‑p sIVENIItCIEKsyK
0 1 S690‑p IItCIEKsyKSIFVL
0 1 Y691‑p ItCIEKsyKSIFVLS
  mouse

 
P47 TRVPKDLPLQTTTLD
T51 KDLPLQTTTLDLSQN
S56 QTTTLDLSQNNISEL
N59 TLDLSQNNISELQTS
S409‑p SLQKLDIsQNSLRYS
G419 SLRYSDGGIPCAWTQ
A423 SDGGIPCAWTQSLLV
T425 GGIPCAWTQSLLVLN
S434 SLLVLNLSSNMLTGS
T532 GNNPFQCTCELRDFV
S681 RNFVPGKSIVENIIN
N688 SIVENIINFIEKSYK
S693 IINFIEKSYKSIFVL
Y694 INFIEKSYKSIFVLS
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