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Protein Page:
DRD4 (human)

Overview
DRD4 Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cell cortex; cell soma; dendritic spine; integral to plasma membrane; membrane; plasma membrane; terminal button; vesicle membrane
Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; identical protein binding; potassium channel regulator activity; protein binding; SH3 domain binding
Biological Process: activation of MAPK activity; adult locomotory behavior; arachidonic acid secretion; behavioral fear response; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; circadian rhythm; dopamine metabolic process; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase inhibiting pathway; fear response; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; olfactory learning; photoperiodism; positive regulation of dopamine uptake; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of calcium-mediated signaling; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; regulation of neurotransmitter secretion; response to amphetamine; response to steroid hormone stimulus; retina development in camera-type eye; short-term memory; social behavior; synaptic transmission, dopaminergic
Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait
Reference #:  P21917 (UniProtKB)
Alt. Names/Synonyms: D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; Dopamine D4 receptor; dopamine receptor D4; DRD4
Gene Symbols: DRD4
Molecular weight: 48,361 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Select Structure to View Below

DRD4

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T159‑p QLLLIGAtWLLsAAV
0 1 S163‑p IGAtWLLsAAVAAPV
0 1 S196 DRDYVVYSSVCSFFL
1 2 S239‑p GRAPRRPsGPGPPsP
1 1 S245‑p PsGPGPPsPTPPAPR
  mouse

 
T154 QLLLIAATWLLSAAV
S158 IAATWLLSAAVASPV
S191‑p NRDYVVYsSVCSFFL
S234 SRAPRRPSGPGPPVS
V240 PSGPGPPVSDPTQGP
  rat

 
T154 QLLLIAATWLLSAAV
S158 IAATWLLSAAVAAPV
S191 DRDYVVYSSICSFFL
S234 SRAPRRPSGPGPPVS
V240 PSGPGPPVSDPTQGP
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