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Protein Page:
DRD4 (human)

DRD4 Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: dopamine binding; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; identical protein binding; protein binding; SH3 domain binding
Biological Process: activation of MAPK activity; adult locomotory behavior; arachidonic acid secretion; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; dopamine metabolic process; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase inhibiting pathway; fear response; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; positive regulation of dopamine uptake; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; response to amphetamine
Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait
Reference #:  P21917 (UniProtKB)
Alt. Names/Synonyms: D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; Dopamine D4 receptor; dopamine receptor D4; DRD4
Gene Symbols: DRD4
Molecular weight: 48,361 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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