Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
Kv1.3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Kv1.3 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: plasma membrane
Molecular Function: delayed rectifier potassium channel activity; voltage-gated ion channel activity
Biological Process: potassium ion transport
Reference #:  P22001 (UniProtKB)
Alt. Names/Synonyms: HGK5; HLK3; HPCN3; HUKIII; KCNA3; KV1.3; MK3; PCN3; potassium channel 3; Potassium voltage-gated channel subfamily A member 3; potassium voltage-gated channel, shaker-related subfamily, member 3; type n potassium channel; Voltage-gated K(+) channel HuKIII; voltage-gated potassium channel protein Kv1.3; Voltage-gated potassium channel subunit Kv1.3
Gene Symbols: KCNA3
Molecular weight: 63,842 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Select Structure to View Below

Kv1.3

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cell growth, induced: Y499‑p, S511‑p, Y529‑p
activity, induced: Y187‑p, Y499‑p
activity, inhibited: Y161‑p, Y162‑p, Y163‑p, Y499‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10‑p ERLSLLRsPPPPSAR
0 1 G80 PPQGGCGGGGCDRYE
0 23 K120‑ub LRFETQLkTLCQFPE
0 1 K134‑ub ETLLGDPkRRMRYFD
1 0 Y161‑p PSFDAILyyyQSGGR
1 0 Y162‑p SFDAILyyyQSGGRI
1 0 Y163‑p FDAILyyyQSGGRIR
1 0 Y187‑p FSEEIRFyQLGEEAM
3 0 Y499‑p EGEEQSQyMHVGsCQ
0 4 S504‑p SQyMHVGsCQHLSSs
0 1 S509 VGsCQHLSSsAEELR
1 2 S511‑p sCQHLSSsAEELRKA
0 1 S520‑p EELRKARsNStLsks
0 1 T523‑p RKARsNStLsksEyM
0 1 S525‑p ARsNStLsksEyMVI
0 5 K526‑ub RsNStLsksEyMVIE
0 3 S527‑p sNStLsksEyMVIEE
1 0 Y529‑p StLsksEyMVIEEGG
0 1 S564‑p TTNNNPNsCVNIkkI
0 10 K569‑ub PNsCVNIkkIFTDV_
0 1 K570‑ub NsCVNIkkIFTDV__
  mouse

 
- gap
S29‑p PPQGGCGsGGGGGGC
K73 LRFETQLKTLCQFPE
K87 ETLLGDPKRRMRYFD
Y114 PSFDAILYYYQSGGR
Y115 SFDAILYYYQSGGRI
Y116 FDAILYYYQSGGRIR
Y140 FSEEIRFYQLGEEAM
Y452 EGEEQAQYMHVGsCQ
S457‑p AQYMHVGsCQHLsSs
S462‑p VGsCQHLsSsAEELR
S464‑p sCQHLsSsAEELRKA
S473 EELRKARSNSTLSKs
T476 RKARSNSTLSKsEYM
S478 ARSNSTLSKsEYMVI
K479 RSNSTLSKsEYMVIE
S480‑p SNSTLSKsEYMVIEE
Y482 STLSKsEYMVIEEGG
S517 TTNNNPNSCVNIKKI
K522 PNSCVNIKKIFTDV_
K523 NSCVNIKKIFTDV__
  rat

 
- gap
S29 PPQGGCVSGGGCDRY
K70 LRFETQLKTLCQFPE
K84 ETLLGDPKRRMRYFD
Y111 PSFDAILYYYQSGGR
Y112 SFDAILYYYQSGGRI
Y113 FDAILYYYQSGGRIR
Y137 FSEEIRFYQLGEEAM
Y449 EGEEQAQYMHVGSCQ
S454 AQYMHVGSCQHLSSS
S459 VGSCQHLSSSAEELR
S461 SCQHLSSSAEELRKA
S470 EELRKARSNSTLSKS
T473 RKARSNSTLSKSEYM
S475 ARSNSTLSKSEYMVI
K476 RSNSTLSKSEYMVIE
S477 SNSTLSKSEYMVIEE
Y479 STLSKSEYMVIEEGG
S514 TTNNNPNSCVNIKKI
K519 PNSCVNIKKIFTDV_
K520 NSCVNIKKIFTDV__
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.