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Protein Page:
GLUT4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLUT4 an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: clathrin-coated vesicle; coated pit; cytoplasmic vesicle membrane; cytosol; endomembrane system; external side of plasma membrane; integral to plasma membrane; lipid raft; membrane; multivesicular body; perinuclear region of cytoplasm; plasma membrane; T-tubule; trans-Golgi network transport vesicle; vesicle membrane
Molecular Function: D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; protein binding
Biological Process: amylopectin biosynthetic process; brown fat cell differentiation; carbohydrate metabolic process; cellular response to insulin stimulus; glucose homeostasis; glucose import; glucose transport; response to ethanol
Disease: Diabetes Mellitus, Noninsulin-dependent
Reference #:  P14672 (UniProtKB)
Alt. Names/Synonyms: Glucose transporter type 4, insulin-responsive; GLUT-4; GLUT4; GTR4; insulin-responsive glucose transporter type 4; SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4; Solute carrier family 2, facilitated glucose transporter member 4
Gene Symbols: SLC2A4
Molecular weight: 54,787 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GLUT4

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S274‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S10 SGFQQIGSEDGEPPQ
0 1 Y56‑p QKVIEQSyNETWLGR
0 1 Y148 GRFLIGAYSGLTSGL
0 1 S149 RFLIGAYSGLTSGLV
0 1 T209 WPLLLGLTVLPALLQ
0 2 K261 SGVLAELKDEKRKLE
1 0 S274‑p LERERPLsLLQLLGs
0 1 S281‑p sLLQLLGsRTHRQPL
0 1 T368‑p CGCAILMtVALLLLE
0 1 T475 VPETRGRTFDQISAA
0 5 T486 ISAAFHRTPsLLEQE
3 7 S488‑p AAFHRTPsLLEQEVK
0 1 K495 sLLEQEVKPSTELEy
0 1 S497 LEQEVKPSTELEyLG
0 2 Y502‑p KPSTELEyLGPDEND
  mouse

 
S10‑p SGFQQIGsDDGEPPR
Y56 QKVIEQSYNATWLGR
Y148‑p GRFLIGAysGLTSGL
S149‑p RFLIGAysGLTSGLV
T209‑p WPLLLALtVLPALLQ
K261‑ub SDALAELkDEKRKLE
S274 LERERPMSLLQLLGS
S281 SLLQLLGSRTHRQPL
T368 CGCAILMTVALLLLE
T475‑p VPETRGRtFDQISAA
T486‑p ISAAFRRtPsLLEQE
S488‑p AAFRRtPsLLEQEVk
K495‑ub sLLEQEVkPsTELEY
S497‑p LEQEVkPsTELEYLG
Y502 kPsTELEYLGPDEND
  rat

 
S10‑p SGFQQIGsEDGEPPQ
Y56 QKVIEQSYNATWLGR
Y148 GRFLIGAYSGLTSGL
S149 RFLIGAYSGLTSGLV
T209 WPLLLAITVLPALLQ
K261 SDALAELKDEKRKLE
S274 LERERPLSLLQLLGS
S281 SLLQLLGSRTHRQPL
T368 CGCAILMTVALLLLE
T475 VPETRGRTFDQISAT
T486‑p ISATFRRtPsLLEQE
S488‑p ATFRRtPsLLEQEVK
K495 sLLEQEVKPSTELEY
S497 LEQEVKPSTELEYLG
Y502 KPSTELEYLGPDEND
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