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Protein Page:
GLUT4 (human)

Overview
GLUT4 an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: clathrin-coated vesicle; endomembrane system; external side of plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; vesicle membrane
Molecular Function: D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; protein binding
Biological Process: carbohydrate metabolic process; cellular response to insulin stimulus; glucose homeostasis; glucose transport
Disease: Diabetes Mellitus, Noninsulin-dependent
Reference #:  P14672 (UniProtKB)
Alt. Names/Synonyms: Glucose transporter type 4, insulin-responsive; GLUT-4; GLUT4; GTR4; insulin-responsive glucose transporter type 4; SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4; Solute carrier family 2, facilitated glucose transporter member 4
Gene Symbols: SLC2A4
Molecular weight: 54,787 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GLUT4

Protein Structure Not Found.


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