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Protein Page:
TCF4 (human)

TCF4 Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2. Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: nuclear chromatin; nucleus; transcription factor complex
Molecular Function: bHLH transcription factor binding; DNA binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activity
Biological Process: positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein-DNA complex assembly; transcription initiation; transcription initiation from RNA polymerase II promoter
Disease: Corneal Dystrophy, Fuchs Endothelial, 3; Pitt-hopkins Syndrome
Reference #:  P15884 (UniProtKB)
Alt. Names/Synonyms: BHLHB19; Class B basic helix-loop-helix protein 19; E2-2; Immunoglobulin transcription factor 2; ITF-2; ITF2; MGC149723; MGC149724; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SL3-3 enhancer factor 2; TCF-4; TCF4; Transcription factor 4
Gene Symbols: TCF4
Molecular weight: 71,308 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
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