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Protein Page:
GPR183 (human)

Overview
GPR183 Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. Signals constitutively through G(i)-alpha, but not throughG(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2). Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q32.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: oxysterol binding
Biological Process: B cell activation during immune response; G-protein coupled receptor protein signaling pathway; humoral immune response; immune response; mature B cell differentiation during immune response; positive regulation of B cell proliferation
Reference #:  P32249 (UniProtKB)
Alt. Names/Synonyms: EBI2; EBV-induced G-protein coupled receptor 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor); Epstein-Barr virus-induced G-protein coupled receptor 2; G protein-coupled receptor 183; G-protein coupled receptor 183; GP183; GPR183
Gene Symbols: GPR183
Molecular weight: 41,224 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
Select Structure to View Below

GPR183

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 9 S328‑p RMLKRQVsVsISsAV
0 3 S330‑p LKRQVsVsISsAVKs
0 5 S333‑p QVsVsISsAVKsAPE
0 2 S337‑p sISsAVKsAPEENsR
0 3 S343‑p KsAPEENsREMtEtQ
0 1 T347‑p EENsREMtEtQMMIH
0 3 T349‑p NsREMtEtQMMIHsK
0 1 S355‑p EtQMMIHsKSSNGK_
  mouse

 
S324‑p KMLKRQVsVsISsAV
S326‑p LKRQVsVsISsAVRS
S329‑p QVsVsISsAVRSAPE
S333 sISsAVRSAPEENsR
S339‑p RSAPEENsREMTEsQ
T343 EENsREMTEsQMMIH
S345‑p NsREMTEsQMMIHSK
S351 EsQMMIHSKASNGR_
  rat

 
S324‑p KMLKRQVsVsISsAV
S326‑p LKRQVsVsISsAVRS
S329‑p QVsVsISsAVRSAPE
S333 sISsAVRSAPEENSR
S339 RSAPEENSREMTESQ
T343 EENSREMTESQMMIH
S345 NSREMTESQMMIHSK
S351 ESQMMIHSKASNGR_
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