Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
SGCA (human)

Overview
SGCA Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCA are the cause of limb-girdle muscular dystrophy type 2D (LGMD2D); also known as Duchenne- like muscular dystrophy autosomal recessive type 2 or severe childhood autosomal recessive muscular dystrophy (SCARMD). LGMD2D is an autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency. The phenotype is less severe than LGMD2C. Belongs to the sarcoglycan alpha/epsilon family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: dystrophin-associated glycoprotein complex; sarcoglycan complex
Molecular Function: protein binding
Biological Process: muscle contraction; muscle development
Disease: Muscular Dystrophy, Limb-girdle, Type 2d
Reference #:  Q16586 (UniProtKB)
Alt. Names/Synonyms: 50 kDa dystrophin-associated glycoprotein; 50-DAG; 50DAG; 50kD DAG; A2; Adhalin; ADL; Alpha-sarcoglycan; Alpha-SG; DAG2; DMDA2; Dystroglycan-2; LGMD2D; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); SCARMD1; SGCA
Gene Symbols: SGCA
Molecular weight: 42,875 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Select Structure to View Below

SGCA

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene