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Protein Page:
NPY2R (human)

Overview
NPY2R Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4q31
Cellular Component: cytosol; integral to plasma membrane; nonmotile primary cilium; plasma membrane
Molecular Function: calcium channel regulator activity; neuropeptide Y receptor activity; peptide YY receptor activity; protein binding; receptor activity
Biological Process: behavioral fear response; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; locomotory behavior; negative regulation of cAMP biosynthetic process; negative regulation of neurological process; negative regulation of secretion; negative regulation of synaptic transmission, glutamatergic; neuropeptide signaling pathway; nitric oxide mediated signal transduction; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of dopamine secretion; positive regulation of peptide secretion; positive regulation of smooth muscle contraction; regulation of sensory perception of pain; secretion
Reference #:  P49146 (UniProtKB)
Alt. Names/Synonyms: Neuropeptide Y receptor type 2; neuropeptide Y receptor Y2; NPY-Y2 receptor; NPY2-R; NPY2R; Y2 receptor
Gene Symbols: NPY2R
Molecular weight: 42,731 Da
Basal Isoelectric point: 6.79  Predict pI for various phosphorylation states
Select Structure to View Below

NPY2R

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T217‑p EEKSIYGtVYSLSSL
0 1 S354 DAIHSEVSVTFKAKK
  mouse

 
T217 EEKSVYGTVYSLSTL
S354‑p DAIHSEVsMTFKAKK
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